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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.11
Chromosome location (bp)
24154168 - 24187959
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Antiviral defense
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
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GO:0002385[mucosal immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0032002[interleukin-28 receptor complex] GO:0034342[response to type III interferon] GO:0038196[type III interferon signaling pathway] GO:0050691[regulation of defense response to virus by host] GO:0051607[defense response to virus] GO:0098586[cellular response to virus] GO:1901857[positive regulation of cellular respiration]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002385[mucosal immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0032002[interleukin-28 receptor complex] GO:0034342[response to type III interferon] GO:0038196[type III interferon signaling pathway] GO:0050691[regulation of defense response to virus by host] GO:0051607[defense response to virus] GO:0098586[cellular response to virus] GO:1901857[positive regulation of cellular respiration]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0002385[mucosal immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0032002[interleukin-28 receptor complex] GO:0034342[response to type III interferon] GO:0038196[type III interferon signaling pathway] GO:0050691[regulation of defense response to virus by host] GO:0051607[defense response to virus] GO:0098586[cellular response to virus] GO:1901857[positive regulation of cellular respiration]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
Show all
GO:0002385[mucosal immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0032002[interleukin-28 receptor complex] GO:0034342[response to type III interferon] GO:0038196[type III interferon signaling pathway] GO:0050691[regulation of defense response to virus by host] GO:0051607[defense response to virus] GO:0098586[cellular response to virus] GO:1901857[positive regulation of cellular respiration]