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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p13.13
Chromosome location (bp)
11254417 - 11256204
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) 1,2. Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity 3. Regulates IFN-gamma (IFNG)- mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins 4,5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Signal transduction inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Growth regulation, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O15524 [Direct mapping] Suppressor of cytokine signaling 1
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Q4JHT5 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 1; cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001817[regulation of cytokine production] GO:0001932[regulation of protein phosphorylation] GO:0004860[protein kinase inhibitor activity] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0009968[negative regulation of signal transduction] GO:0010533[regulation of activation of Janus kinase activity] GO:0016567[protein ubiquitination] GO:0019210[kinase inhibitor activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0035556[intracellular signal transduction] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042509[regulation of tyrosine phosphorylation of STAT protein] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0045444[fat cell differentiation] GO:0045591[positive regulation of regulatory T cell differentiation] GO:0046425[regulation of receptor signaling pathway via JAK-STAT] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060334[regulation of type II interferon-mediated signaling pathway] GO:0071230[cellular response to amino acid stimulus]
O15524 [Direct mapping] Suppressor of cytokine signaling 1
Show all
Q4JHT5 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 1; cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001932[regulation of protein phosphorylation] GO:0004860[protein kinase inhibitor activity] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0019210[kinase inhibitor activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0035556[intracellular signal transduction] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0045591[positive regulation of regulatory T cell differentiation] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060334[regulation of type II interferon-mediated signaling pathway]
The Human Protein Atlas project is funded
