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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.3
Chromosome location (bp)
144291591 - 144314720
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form 19,20,21. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes 22,23,24,25,26,27,28,29,30,31,32,33,34,35. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival 36. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form 37,38. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences 39,40. Binds to chromatin at heat shock gene promoters 41. Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 42. Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells 43. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner 44. Plays a role in nuclear export of stress-induced HSP70 mRNA 45. Plays a role in the regulation of mitotic progression 46. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner 47. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner 48....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair, Host-virus interaction, mRNA processing, mRNA transport, Stress response, Transcription, Transcription regulation, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q00613 [Direct mapping] Heat shock factor protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000792[heterochromatin] GO:0000922[spindle pole] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001162[RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006397[mRNA processing] GO:0006952[defense response] GO:0006974[cellular response to DNA damage stimulus] GO:0007584[response to nutrient] GO:0009299[mRNA transcription] GO:0009408[response to heat] GO:0010243[response to organonitrogen compound] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010667[negative regulation of cardiac muscle cell apoptotic process] GO:0014070[response to organic cyclic compound] GO:0014823[response to activity] GO:0016605[PML body] GO:0019901[protein kinase binding] GO:0031072[heat shock protein binding] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0033574[response to testosterone] GO:0034605[cellular response to heat] GO:0034620[cellular response to unfolded protein] GO:0035865[cellular response to potassium ion] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042802[identical protein binding] GO:0043200[response to amino acid] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045651[positive regulation of macrophage differentiation] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0051028[mRNA transport] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051879[Hsp90 protein binding] GO:0061770[translation elongation factor binding] GO:0065003[protein-containing complex assembly] GO:0070301[cellular response to hydrogen peroxide] GO:0071222[cellular response to lipopolysaccharide] GO:0071230[cellular response to amino acid stimulus] GO:0071276[cellular response to cadmium ion] GO:0071280[cellular response to copper ion] GO:0071392[cellular response to estradiol stimulus] GO:0071407[cellular response to organic cyclic compound] GO:0071466[cellular response to xenobiotic stimulus] GO:0071478[cellular response to radiation] GO:0071480[cellular response to gamma radiation] GO:0072738[cellular response to diamide] GO:0090084[negative regulation of inclusion body assembly] GO:0090261[positive regulation of inclusion body assembly] GO:0097165[nuclear stress granule] GO:0097431[mitotic spindle pole] GO:0097677[STAT family protein binding] GO:0098847[sequence-specific single stranded DNA binding] GO:0101031[chaperone complex] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0140296[general transcription initiation factor binding] GO:1900034[regulation of cellular response to heat] GO:1900365[positive regulation of mRNA polyadenylation] GO:1901215[negative regulation of neuron death] GO:1901652[response to peptide] GO:1902512[positive regulation of apoptotic DNA fragmentation] GO:1903936[cellular response to sodium arsenite] GO:1904385[cellular response to angiotensin] GO:1904528[positive regulation of microtubule binding] GO:1904843[cellular response to nitroglycerin] GO:1904845[cellular response to L-glutamine] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990841[promoter-specific chromatin binding] GO:1990904[ribonucleoprotein complex] GO:1990910[response to hypobaric hypoxia] GO:1990911[response to psychosocial stress] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
The Human Protein Atlas project is funded
