GENERAL INFORMATIONi
Gene namei ANXA2
Synonyms ANX2, ANX2L4, CAL1H, LIP2, LPC2D
Gene descriptioni Annexin A2
Protein classi Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Transporters
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 15
Cytoband q22.2
Chromosome location (bp) 60347134 - 60402883
Number of transcriptsi 31
Ensembl ENSG00000182718 (version 109)
Entrez gene 302
HGNC HGNC:537
UniProt P07355 (UniProt - Evidence at protein level)
neXtProt NX_P07355
GeneCards ANXA2
Antibodypedia ANXA2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 1, 2, 3. show less
Molecular function (UniProt)i RNA-binding
Biological process (UniProt)i Host-virus interaction
Ligand (UniProt)i Calcium, Calcium/phospholipid-binding
Gene summary (Entrez)i This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ANXA2-201
ENSP00000346032
ENST00000332680
P07355
[Direct mapping] Annexin A2
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 357 aa
40.4 kDa 		No 0
ANXA2-202
ENSP00000379342
ENST00000396024
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-203
ENSP00000411352
ENST00000421017
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-204
ENSP00000387545
ENST00000451270
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001533 [cornified envelope]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005811 [lipid droplet]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030199 [collagen fibril organization]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0035749 [myelin sheath adaxonal region]
GO:0036035 [osteoclast development]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042730 [fibrinolysis]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0051099 [positive regulation of binding]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-206
ENSP00000452958
ENST00000557904
H0YKV8
[Direct mapping] Annexin A2
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 81 aa
9 kDa 		No 0
ANXA2-207
ENSP00000452895
ENST00000557906
P07355
[Direct mapping] Annexin A2
Show all
H0YKS4
[Direct mapping] Annexin
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-209
ENSP00000453742
ENST00000557986
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 4 aa
0.5 kDa 		No 0
ANXA2-210
ENSP00000454096
ENST00000558132
H0YNP5
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 175 aa
19.7 kDa 		No 0
ANXA2-213
ENSP00000452981
ENST00000558558
P07355
[Direct mapping] Annexin A2
Show all
H0YKX9
[Direct mapping] Annexin
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-214
ENSP00000453039
ENST00000558985
H0YL33
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 222 aa
25.9 kDa 		No 0
ANXA2-215
ENSP00000453739
ENST00000558986
H0YMT9
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 133 aa
14.5 kDa 		No 0
ANXA2-216
ENSP00000453925
ENST00000558998
H0YNA0
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 79 aa
9.1 kDa 		No 0
ANXA2-217
ENSP00000453869
ENST00000559113
H0YL33
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 222 aa
25.9 kDa 		No 0
ANXA2-218
ENSP00000453464
ENST00000559176
H0YM50
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 248 aa
28.3 kDa 		No 0
ANXA2-219
ENSP00000453663
ENST00000559350
H0YMM1
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 149 aa
16.5 kDa 		No 0
ANXA2-220
ENSP00000453566
ENST00000559370
H0YMD9
[Direct mapping] Annexin A2
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 65 aa
7.1 kDa 		No 0
ANXA2-221
ENSP00000453000
ENST00000559467
H0YKZ7
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 119 aa
13 kDa 		No 0
ANXA2-224
ENSP00000453174
ENST00000559725
H0YLE2
[Direct mapping] Annexin A2
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
Show all
 45 aa
5.3 kDa 		No 0
ANXA2-225
ENSP00000453770
ENST00000559780
H0YMW4
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 367 aa
41.9 kDa 		No 0
ANXA2-226
ENSP00000453859
ENST00000559818
P07355
[Direct mapping] Annexin A2
Show all
H0YN42
[Direct mapping] Annexin
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-227
ENSP00000453694
ENST00000559956
P07355
[Direct mapping] Annexin A2
Show all
H0YKZ7
[Direct mapping] Annexin
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-229
ENSP00000452921
ENST00000560165
H0YKS4
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 176 aa
19.5 kDa 		No 0
ANXA2-230
ENSP00000453556
ENST00000560367
H0YMD0
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 227 aa
25.3 kDa 		No 0
ANXA2-231
ENSP00000453579
ENST00000560389
H0YKS4
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 176 aa
19.5 kDa 		No 0
ANXA2-232
ENSP00000453841
ENST00000560466
H0YN28
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0016020 [membrane]
Show all
 139 aa
16.1 kDa 		No 0
ANXA2-233
ENSP00000452858
ENST00000560468
P07355
[Direct mapping] Annexin A2
Show all
H0YKL9
[Direct mapping] Annexin
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-241
ENSP00000503447
ENST00000677968
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-242
ENSP00000503855
ENST00000678061
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-243
ENSP00000504164
ENST00000678450
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-245
ENSP00000503757
ENST00000678870
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-246
ENSP00000504035
ENST00000679109
P07355
[Direct mapping] Annexin A2
Show all
A0A024R5Z7
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0001786 [phosphatidylserine binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0003723 [RNA binding]
GO:0004859 [phospholipase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006900 [vesicle budding from membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010756 [positive regulation of plasminogen activation]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035578 [azurophil granule lumen]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0044090 [positive regulation of vacuole organization]
GO:0044548 [S100 protein binding]
GO:0045121 [membrane raft]
GO:0045921 [positive regulation of exocytosis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046790 [virion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0050767 [regulation of neurogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:0098797 [plasma membrane protein complex]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905597 [positive regulation of low-density lipoprotein particle receptor binding]
GO:1905599 [positive regulation of low-density lipoprotein receptor activity]
GO:1905602 [positive regulation of receptor-mediated endocytosis involved in cholesterol transport]
GO:1905686 [positive regulation of plasma membrane repair]
GO:1990665 [AnxA2-p11 complex]
GO:1990667 [PCSK9-AnxA2 complex]
Show all
 339 aa
38.6 kDa 		No 0

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