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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Potassium two pore domain channel subfamily K member 4
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets Voltage-gated ion channels
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.1
Chromosome location (bp)
64291302 - 64300031
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Voltage-insensitive potassium channel 1. Channel opening is triggered by mechanical forces that deform the membrane 2,3,4,5. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ion channel, Potassium channel, Voltage-gated channel
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Potassium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
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GO:0005244[voltage-gated ion channel activity] GO:0005267[potassium channel activity] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0015271[outward rectifier potassium channel activity] GO:0016020[membrane] GO:0019233[sensory perception of pain] GO:0022841[potassium ion leak channel activity] GO:0030322[stabilization of membrane potential] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0050951[sensory perception of temperature stimulus] GO:0050976[detection of mechanical stimulus involved in sensory perception of touch] GO:0071260[cellular response to mechanical stimulus] GO:0071398[cellular response to fatty acid] GO:0071469[cellular response to alkaline pH] GO:0071502[cellular response to temperature stimulus] GO:0071805[potassium ion transmembrane transport] GO:0097604[temperature-gated cation channel activity] GO:0098782[mechanosensitived potassium channel activity]
Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
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GO:0005244[voltage-gated ion channel activity] GO:0005267[potassium channel activity] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0007613[memory] GO:0015271[outward rectifier potassium channel activity] GO:0016020[membrane] GO:0019233[sensory perception of pain] GO:0022841[potassium ion leak channel activity] GO:0030322[stabilization of membrane potential] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0050951[sensory perception of temperature stimulus] GO:0050976[detection of mechanical stimulus involved in sensory perception of touch] GO:0071260[cellular response to mechanical stimulus] GO:0071398[cellular response to fatty acid] GO:0071469[cellular response to alkaline pH] GO:0071502[cellular response to temperature stimulus] GO:0071805[potassium ion transmembrane transport] GO:0097604[temperature-gated cation channel activity] GO:0098782[mechanosensitived potassium channel activity]
F5GYE0 [Direct mapping] Potassium channel subfamily K member 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders
Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005267[potassium channel activity] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0015271[outward rectifier potassium channel activity] GO:0016020[membrane] GO:0019233[sensory perception of pain] GO:0022841[potassium ion leak channel activity] GO:0030322[stabilization of membrane potential] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0050951[sensory perception of temperature stimulus] GO:0050976[detection of mechanical stimulus involved in sensory perception of touch] GO:0071260[cellular response to mechanical stimulus] GO:0071398[cellular response to fatty acid] GO:0071469[cellular response to alkaline pH] GO:0071502[cellular response to temperature stimulus] GO:0071805[potassium ion transmembrane transport] GO:0097604[temperature-gated cation channel activity] GO:0098782[mechanosensitived potassium channel activity]
The Human Protein Atlas project is funded
