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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
7957537 - 7965447
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID 1. Displays anti-inflammatory activity 2. Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection 3. Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens 4. Exhibits both ATPase and GTPase activities 5....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q86W26 [Direct mapping] NACHT, LRR and PYD domains-containing protein 10
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000166[nucleotide binding] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0003924[GTPase activity] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0016020[membrane] GO:0016887[ATP hydrolysis activity] GO:0019897[extrinsic component of plasma membrane] GO:0032730[positive regulation of interleukin-1 alpha production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0045087[innate immune response] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0050829[defense response to Gram-negative bacterium] GO:0050832[defense response to fungus] GO:1900426[positive regulation of defense response to bacterium] GO:2000318[positive regulation of T-helper 17 type immune response]
Q86W26 [Direct mapping] NACHT, LRR and PYD domains-containing protein 10
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000166[nucleotide binding] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0003924[GTPase activity] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0016020[membrane] GO:0016887[ATP hydrolysis activity] GO:0019897[extrinsic component of plasma membrane] GO:0032730[positive regulation of interleukin-1 alpha production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0045087[innate immune response] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0050829[defense response to Gram-negative bacterium] GO:0050832[defense response to fungus] GO:1900426[positive regulation of defense response to bacterium] GO:2000318[positive regulation of T-helper 17 type immune response]
The Human Protein Atlas project is funded
