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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
21
Cytoband
Chromosome location (bp)
14961235 - 15065936
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P48552 [Direct mapping] Nuclear receptor-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001543[ovarian follicle rupture] GO:0001650[fibrillar center] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007623[circadian rhythm] GO:0016607[nuclear speck] GO:0016922[nuclear receptor binding] GO:0019915[lipid storage] GO:0030331[nuclear estrogen receptor binding] GO:0030728[ovulation] GO:0032922[circadian regulation of gene expression] GO:0035259[nuclear glucocorticoid receptor binding] GO:0042826[histone deacetylase binding] GO:0042974[nuclear retinoic acid receptor binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0048511[rhythmic process] GO:0071392[cellular response to estradiol stimulus]
P48552 [Direct mapping] Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001650[fibrillar center] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007623[circadian rhythm] GO:0016922[nuclear receptor binding] GO:0030331[nuclear estrogen receptor binding] GO:0032922[circadian regulation of gene expression] GO:0035259[nuclear glucocorticoid receptor binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0048511[rhythmic process] GO:0071392[cellular response to estradiol stimulus]
P48552 [Direct mapping] Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001650[fibrillar center] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007623[circadian rhythm] GO:0016922[nuclear receptor binding] GO:0030331[nuclear estrogen receptor binding] GO:0032922[circadian regulation of gene expression] GO:0035259[nuclear glucocorticoid receptor binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046965[nuclear retinoid X receptor binding] GO:0048511[rhythmic process] GO:0071392[cellular response to estradiol stimulus]
C9J130 [Direct mapping] Nuclear receptor-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the urinary system Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0005102[signaling receptor binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1B0GUG9 [Direct mapping] Nuclear receptor-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the urinary system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
