Brain tissue expression of TH - Mouse brain

MOUSE BRAIN TISSUE

Gene description	Tyrosine hydroxylase
Mouse gene	ENSMUSG00000000214 (version 10)
Annotation summary	In agreement with literature data, this antibody stains the dopmaminergic (A8-16), noradrenergic (A1-7) and adrenergic (C1-C3) neuronal cell bodies and their dendrites and axonal arborization throughout the brain. Besides of cell bodies in A1-16 and C1-3 groups, strong axonal staining is noticed in the glomerular layer of the olfactory bulb, caudate putamen, nucleus accumbens, olfactory tubercule and basolateral amygdala. Weak-moderate axonal staining is noticed in the cortex, hippocampus, (lateral) septum, BNST, hypothalamus, -, external-internal plexiform layers and granular layer of the olfactory bulb, periaqueductal gray matter, parabrachial region and cerebellar molecular layer.
Positive cells and structuresⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.	Soma, dendrite and axon in neurons.

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Human caudate

Caudate and putamen

Hypothalamus

Amygdala

Pons

Midbrain

	Protein
	Relative fluorescence intensityⁱ Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity .
Mouse brain region	255 0
Cerebral cortex
Frontal association cortex (fra)	N/A
Motor cortex (m)
Cingulate cortex (cg)
Piriform cortex, L1 (pirl1)	N/A
Piriform cortex, L2 (pirl2)	N/A
Piriform cortex, L3 (pirl3)	N/A
Insular cortex (i)	N/A
Somatosensory cortex (s)
Retrosplenial granular cortex (rsg)
Parietal association cortex (p)	N/A
Entorhinal cortex (ent)
Visual cortex (v)
Olfactory bulb
Anterior olfactory nucleus (aon)
Granule cell layer (gro)
Internal plexiform layer (ipl)
Mitral cell layer (mi)
Glomerular layer (gl)
Rostral migratory stream (rms)
External plexiform layer (epl)
External plexiform layer of the accessory OB (epla)
Granule cell layer of the accessory OB (gra)
Glomerular layer of the accessory OB (gla)
Hippocampus
Polymorph layer of the dentate gyrus (podg)
Molecular layer of the dentate gyrus (modg)
Granular dentate gyrus (grdg)
CA1 - oriens layer (ca1or)
CA1 - pyramidal layer (ca1py)
CA1 - radiatum layer (ca1ra)
CA2 - oriens layer (ca2or)
CA2 - pyramidal layer (ca2py)
CA2 - radiatum layer (ca2ra)
CA3 - oriens layer (ca3or)
CA3 - pyramidal layer (ca3py)
CA3 - radiatum layer (ca3ra)
Stratum lucidum (slu)
Lacunosum moleculare (lmol)
Subiculum (sub)
Amygdala
Nucleus of the lateral olfactory tract (lot)
Basal medial amygdaloid nucleus (bma)
Basal lateral amygdala* (*bla)	N/A
Basal lateral amygdaloid nucleus (bla)
Cortical amygdala (aco)
Central amygdala (ce)
Medial amygdaloid nucleus (mea)
Thalamus
Medial geniculate nucleus (mg)
Parafascicular thalamic nucleus (pf)	N/A
Pregeniculate nucleus (pg)
Stria terminalis (st)
Zona incerta (zi)
Anterodorsal thalamic nucleus (ad)
Reticular thalamic nucleus (rt)
Vental anterior thalamic nucleus (va)
Medial habenular nucleus (mhb)
Laterodorsal thalamic area (ld)	N/A
Paraventricular thalamic nucleus (pv)
Central medial thalamic area (cm)
Ventral lateral thalamic area (vl)	N/A
Ventral medial thalamic area (vm)	N/A
Lateral habenulal nucleus (lhb)
Ventral posterior thalamus (vpt)	N/A
Anterior pretactal nucleus (apt)	N/A
Retromammillary nucleus (rm)	N/A
Hypothalamus
Dorsal tuberomammillary nucleus (dtm)	N/A
Mammillary nucleus (mn)
Periventricular hypothalamic nucleus (pe)
Supraoptic nucleus (so)
Tuberal nucleus (tu)	N/A
Ventral tuberomammillary nucleus (vtm)	N/A
Lateral preoptic area (lpo)
Medial preoptic area (mpo)
Suprachiasmatic nucleus (sch)
Paraventricular hypothalamic nucleus (pa)
Anterior hypothalamic area, central (ahc)
Ventral medial hypothalamic nucleus (vmh)	N/A
Ventral medial hypothalamic nucleus* (*vmh)	N/A
Arcuate nucleus (arc)	N/A
Arcuate nucleus* (*arc)	N/A
Peduncular part of lateral hypothalmus (plh)
Dorsal medial hypothalamic nucleus (dm)	N/A
Stria terminalis* (*st)	N/A
Cerebellum
Vestibulocerebellar nucleus (vecb)	N/A
Moleuclar layer of the cerebellum (cemol)
Purkinje layer of the cerebellum (cepur)
Granular layer of the cerebellum (cegr)
Pons
Barrington's nucleus (bar)	N/A
Koelliker-fuse nucleus (kf)	N/A
Motor tregiminal nucleus (5n)
Parabrachial nucleus (pbp)
Principle sensory trigeminal nucleus (pr5)
Locus coeruleus (lc)
Pontine nucleus (pn)
Vestibular nucleus (ve)
Pontine reticular nucleus, oral (pno)
Lateral lemniscus (ll)
Superior paraolivary nucleus (spo)
Medulla oblongata
Nucleus of the solitary tract (sol)
Raphe magnus nucleus (rmg)
Cochlear nucleus (cn)
Lateral paragigantocellular nucleus (lpg)
Raphe pallidus nucleus (rpa)
Facial nucleus (7n)
Hypoglossal nucleus (12n)	N/A
Ambiguus nucleus (amb)
External cuneate nucleus (ecu)
Inferior olivary nucleus (io)
Raphe obscures nucleus (rob)
Dorsal motor nucleus of vagus (10n)	N/A
Circumventricular organs
Subcommissural organ (sco)
Subfornical organ (sfo)
Median eminence (me)	N/A
Medulla (ap)	N/A

Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.
HPA013768