We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q23.3
Chromosome location (bp)
64465499 - 64474503
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors 1. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses 2. Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007268[chemical synaptic transmission] GO:0008179[adenylate cyclase binding] GO:0008287[protein serine/threonine phosphatase complex] GO:0009898[cytoplasmic side of plasma membrane] GO:0010738[regulation of protein kinase A signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0030346[protein phosphatase 2B binding] GO:0031698[beta-2 adrenergic receptor binding] GO:0032590[dendrite membrane] GO:0034237[protein kinase A regulatory subunit binding] GO:0035254[glutamate receptor binding] GO:0043197[dendritic spine] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045762[positive regulation of adenylate cyclase activity] GO:0050811[GABA receptor binding] GO:0051018[protein kinase A binding] GO:0060076[excitatory synapse] GO:0060090[molecular adaptor activity] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097110[scaffold protein binding] GO:0098837[postsynaptic recycling endosome] GO:0110165[cellular anatomical entity] GO:1900273[positive regulation of long-term synaptic potentiation] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905751[positive regulation of endosome to plasma membrane protein transport]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007268[chemical synaptic transmission] GO:0008179[adenylate cyclase binding] GO:0008287[protein serine/threonine phosphatase complex] GO:0009898[cytoplasmic side of plasma membrane] GO:0010738[regulation of protein kinase A signaling] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0030346[protein phosphatase 2B binding] GO:0031698[beta-2 adrenergic receptor binding] GO:0032590[dendrite membrane] GO:0034237[protein kinase A regulatory subunit binding] GO:0035254[glutamate receptor binding] GO:0043197[dendritic spine] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045762[positive regulation of adenylate cyclase activity] GO:0050811[GABA receptor binding] GO:0051018[protein kinase A binding] GO:0060076[excitatory synapse] GO:0060090[molecular adaptor activity] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097110[scaffold protein binding] GO:0098837[postsynaptic recycling endosome] GO:0110165[cellular anatomical entity] GO:1900273[positive regulation of long-term synaptic potentiation] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905751[positive regulation of endosome to plasma membrane protein transport]
The Human Protein Atlas project is funded
