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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q24.13
Chromosome location (bp)
112418351 - 112509918
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus 1,2,3,4,5. Positively regulates MAPK signal transduction pathway 6. Dephosphorylates GAB1, ARHGAP35 and EGFR 7. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity 8. Dephosphorylates CDC73 9. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L 10....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q06124 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006629[lipid metabolic process] GO:0006641[triglyceride metabolic process] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007409[axonogenesis] GO:0007420[brain development] GO:0007507[heart development] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009755[hormone-mediated signaling pathway] GO:0009967[positive regulation of signal transduction] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0021697[cerebellar cortex formation] GO:0030159[signaling receptor complex adaptor activity] GO:0030220[platelet formation] GO:0030971[receptor tyrosine kinase binding] GO:0031295[T cell costimulation] GO:0032331[negative regulation of chondrocyte differentiation] GO:0032528[microvillus organization] GO:0032728[positive regulation of interferon-beta production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0033277[abortive mitotic cell cycle] GO:0033628[regulation of cell adhesion mediated by integrin] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0035264[multicellular organism growth] GO:0035265[organ growth] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0035855[megakaryocyte development] GO:0036302[atrioventricular canal development] GO:0038127[ERBB signaling pathway] GO:0042445[hormone metabolic process] GO:0042593[glucose homeostasis] GO:0043254[regulation of protein-containing complex assembly] GO:0043408[regulation of MAPK cascade] GO:0045296[cadherin binding] GO:0045778[positive regulation of ossification] GO:0045931[positive regulation of mitotic cell cycle] GO:0046326[positive regulation of glucose import] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046676[negative regulation of insulin secretion] GO:0046825[regulation of protein export from nucleus] GO:0046887[positive regulation of hormone secretion] GO:0046888[negative regulation of hormone secretion] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048011[neurotrophin TRK receptor signaling pathway] GO:0048013[ephrin receptor signaling pathway] GO:0048609[multicellular organismal reproductive process] GO:0048806[genitalia development] GO:0048839[inner ear development] GO:0048873[homeostasis of number of cells within a tissue] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839[cell adhesion molecule binding] GO:0051428[peptide hormone receptor binding] GO:0051463[negative regulation of cortisol secretion] GO:0060020[Bergmann glial cell differentiation] GO:0060125[negative regulation of growth hormone secretion] GO:0060325[face morphogenesis] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0061582[intestinal epithelial cell migration] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071310[cellular response to organic substance] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1990782[protein tyrosine kinase binding]
Q06124 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007420[brain development] GO:0007507[heart development] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030159[signaling receptor complex adaptor activity] GO:0030971[receptor tyrosine kinase binding] GO:0031295[T cell costimulation] GO:0032331[negative regulation of chondrocyte differentiation] GO:0032728[positive regulation of interferon-beta production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0033628[regulation of cell adhesion mediated by integrin] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0036302[atrioventricular canal development] GO:0038127[ERBB signaling pathway] GO:0043254[regulation of protein-containing complex assembly] GO:0045296[cadherin binding] GO:0045778[positive regulation of ossification] GO:0046326[positive regulation of glucose import] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0048013[ephrin receptor signaling pathway] GO:0048806[genitalia development] GO:0048839[inner ear development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839[cell adhesion molecule binding] GO:0060325[face morphogenesis] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071310[cellular response to organic substance] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1990782[protein tyrosine kinase binding]
H0YF12 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q06124 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007420[brain development] GO:0007507[heart development] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030159[signaling receptor complex adaptor activity] GO:0030971[receptor tyrosine kinase binding] GO:0031295[T cell costimulation] GO:0032331[negative regulation of chondrocyte differentiation] GO:0032728[positive regulation of interferon-beta production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0033628[regulation of cell adhesion mediated by integrin] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0036302[atrioventricular canal development] GO:0038127[ERBB signaling pathway] GO:0043254[regulation of protein-containing complex assembly] GO:0045296[cadherin binding] GO:0045778[positive regulation of ossification] GO:0046326[positive regulation of glucose import] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0048013[ephrin receptor signaling pathway] GO:0048806[genitalia development] GO:0048839[inner ear development] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839[cell adhesion molecule binding] GO:0060325[face morphogenesis] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071310[cellular response to organic substance] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1990782[protein tyrosine kinase binding]
A0A0U1RRI0 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A8I5QL30 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
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GO:0004725[protein tyrosine phosphatase activity] GO:0006470[protein dephosphorylation] GO:0070887[cellular response to chemical stimulus]
A0A8I5KW48 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 11
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Protein evidence (Ezkurdia et al 2014)
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GO:0004725[protein tyrosine phosphatase activity] GO:0006470[protein dephosphorylation] GO:0016311[dephosphorylation] GO:0016791[phosphatase activity] GO:0070887[cellular response to chemical stimulus]
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