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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p24.2
Chromosome location (bp)
17753858 - 17788946
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation 1,2. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction 3. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA 4. Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Endonuclease, Hydrolase, Nuclease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q17RS7 [Direct mapping] Flap endonuclease GEN homolog 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000287[magnesium ion binding] GO:0000400[four-way junction DNA binding] GO:0000724[double-strand break repair via homologous recombination] GO:0003677[DNA binding] GO:0003824[catalytic activity] GO:0004518[nuclease activity] GO:0004519[endonuclease activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005813[centrosome] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010824[regulation of centrosome duplication] GO:0016787[hydrolase activity] GO:0017108[5'-flap endonuclease activity] GO:0031297[replication fork processing] GO:0042803[protein homodimerization activity] GO:0046872[metal ion binding] GO:0071139[resolution of recombination intermediates] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090305[nucleic acid phosphodiester bond hydrolysis]
Q17RS7 [Direct mapping] Flap endonuclease GEN homolog 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000287[magnesium ion binding] GO:0000400[four-way junction DNA binding] GO:0000724[double-strand break repair via homologous recombination] GO:0003677[DNA binding] GO:0003824[catalytic activity] GO:0004518[nuclease activity] GO:0004519[endonuclease activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005813[centrosome] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010824[regulation of centrosome duplication] GO:0016787[hydrolase activity] GO:0017108[5'-flap endonuclease activity] GO:0031297[replication fork processing] GO:0042803[protein homodimerization activity] GO:0046872[metal ion binding] GO:0071139[resolution of recombination intermediates] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090305[nucleic acid phosphodiester bond hydrolysis]
E9PLG0 [Direct mapping] Flap endonuclease GEN homolog 1
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004518[nuclease activity] GO:0090305[nucleic acid phosphodiester bond hydrolysis]
E9PM30 [Direct mapping] Flap endonuclease GEN homolog 1
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004518[nuclease activity] GO:0090305[nucleic acid phosphodiester bond hydrolysis]
The Human Protein Atlas project is funded
