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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q21.3
Chromosome location (bp)
128879596 - 128924003
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation 1,2,3. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs 4,5,6,7. However, in vivo, it does not seem to play a primary role in fatty acid oxidation 8,9. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein 10....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
FAD, Flavoprotein
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H845 [Direct mapping] Complex I assembly factor ACAD9, mitochondrial
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Metabolic proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
D6RCD8 [Direct mapping] Complex I assembly factor ACAD9, mitochondrial
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Metabolic proteins MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0005739[mitochondrion] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660[flavin adenine dinucleotide binding]
Q9H9W4 [Direct mapping] Acyl-Coenzyme A dehydrogenase family, member 9, isoform CRA_b; Complex I assembly factor ACAD9, mitochondrial; cDNA FLJ12506 fis, clone NT2RM2001700, weakly similar to ACYL-COA DEHYDROGENASE, VERY-LONG-CHAIN SPECIFIC; cDNA FLJ53144, highly similar to Acyl-CoA dehydrogenase family member 9, mitochondrial
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Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003995[acyl-CoA dehydrogenase activity] GO:0005739[mitochondrion] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660[flavin adenine dinucleotide binding]
A0A7P0T7Z1 [Direct mapping] Complex I assembly factor ACAD9, mitochondrial
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Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003995[acyl-CoA dehydrogenase activity] GO:0005739[mitochondrion] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660[flavin adenine dinucleotide binding]
A0A7P0T8U3 [Direct mapping] Complex I assembly factor ACAD9, mitochondrial
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Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003995[acyl-CoA dehydrogenase activity] GO:0005739[mitochondrion] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660[flavin adenine dinucleotide binding]
A0A7P0T9N9 [Direct mapping] Complex I assembly factor ACAD9, mitochondrial
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Metabolic proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mitochondrial diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003995[acyl-CoA dehydrogenase activity] GO:0005739[mitochondrion] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660[flavin adenine dinucleotide binding]
The Human Protein Atlas project is funded
