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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
45812576 - 45816957
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O00762 [Direct mapping] Ubiquitin-conjugating enzyme E2 C
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Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0010458[exit from mitosis] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031536[positive regulation of exit from mitosis] GO:0032446[protein modification by small protein conjugation] GO:0044389[ubiquitin-like protein ligase binding] GO:0051301[cell division] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1904668[positive regulation of ubiquitin protein ligase activity]
O00762 [Direct mapping] Ubiquitin-conjugating enzyme E2 C
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0010458[exit from mitosis] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031536[positive regulation of exit from mitosis] GO:0032446[protein modification by small protein conjugation] GO:0044389[ubiquitin-like protein ligase binding] GO:0051301[cell division] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1904668[positive regulation of ubiquitin protein ligase activity]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0010458[exit from mitosis] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031536[positive regulation of exit from mitosis] GO:0032446[protein modification by small protein conjugation] GO:0044389[ubiquitin-like protein ligase binding] GO:0051301[cell division] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1904668[positive regulation of ubiquitin protein ligase activity]
O00762 [Direct mapping] Ubiquitin-conjugating enzyme E2 C
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0010458[exit from mitosis] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031536[positive regulation of exit from mitosis] GO:0032446[protein modification by small protein conjugation] GO:0044389[ubiquitin-like protein ligase binding] GO:0051301[cell division] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1904668[positive regulation of ubiquitin protein ligase activity]
The Human Protein Atlas project is funded
