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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q26.13
Chromosome location (bp)
124984317 - 125161170
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NAD
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P56545 [Direct mapping] C-terminal-binding protein 2
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016081[synaptic vesicle docking] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0035563[positive regulation of chromatin binding] GO:0042974[nuclear retinoic acid receptor binding] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0097470[ribbon synapse] GO:0098684[photoreceptor ribbon synapse] GO:0098831[presynaptic active zone cytoplasmic component] GO:0098882[structural constituent of presynaptic active zone] GO:0098978[glutamatergic synapse] GO:0098982[GABA-ergic synapse] GO:0099523[presynaptic cytosol] GO:0140297[DNA-binding transcription factor binding] GO:1990830[cellular response to leukemia inhibitory factor]
P56545 [Direct mapping] C-terminal-binding protein 2
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0042802[identical protein binding] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0140297[DNA-binding transcription factor binding]
P56545 [Direct mapping] C-terminal-binding protein 2
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0140297[DNA-binding transcription factor binding]
P56545 [Direct mapping] C-terminal-binding protein 2
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0140297[DNA-binding transcription factor binding]
P56545 [Direct mapping] C-terminal-binding protein 2
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0140297[DNA-binding transcription factor binding]
P56545 [Direct mapping] C-terminal-binding protein 2
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048386[positive regulation of retinoic acid receptor signaling pathway] GO:0048790[maintenance of presynaptic active zone structure] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0140297[DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
