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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q33.3
Chromosome location (bp)
108207439 - 108218368
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination 1,2,3,4,5,6,7,8. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed 9,10,11,12. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction 13,14,15,16. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps 17. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 18,19. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends 20. LIG4 regulates nuclear localization of XRCC4 21....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ligase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
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Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010212[response to ionizing radiation] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0022008[neurogenesis] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048144[fibroblast proliferation] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071285[cellular response to lithium ion] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0072089[stem cell proliferation] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:1904155[DN2 thymocyte differentiation] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
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Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
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Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]
A0A024RE06 [Target identity:100%; Query identity:100%] DNA ligase
Show all
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012[single strand break repair] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0000793[condensed chromosome] GO:0001701[in utero embryonic development] GO:0002328[pro-B cell differentiation] GO:0003677[DNA binding] GO:0003909[DNA ligase activity] GO:0003910[DNA ligase (ATP) activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005958[DNA-dependent protein kinase-DNA ligase 4 complex] GO:0006260[DNA replication] GO:0006266[DNA ligation] GO:0006281[DNA repair] GO:0006297[nucleotide-excision repair, DNA gap filling] GO:0006302[double-strand break repair] GO:0006303[double-strand break repair via nonhomologous end joining] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007417[central nervous system development] GO:0008022[protein C-terminus binding] GO:0008283[cell population proliferation] GO:0010165[response to X-ray] GO:0010332[response to gamma radiation] GO:0016874[ligase activity] GO:0032807[DNA ligase IV complex] GO:0033077[T cell differentiation in thymus] GO:0033151[V(D)J recombination] GO:0033152[immunoglobulin V(D)J recombination] GO:0033153[T cell receptor V(D)J recombination] GO:0035019[somatic stem cell population maintenance] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043524[negative regulation of neuron apoptotic process] GO:0045190[isotype switching] GO:0046872[metal ion binding] GO:0048146[positive regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051102[DNA ligation involved in DNA recombination] GO:0051103[DNA ligation involved in DNA repair] GO:0051276[chromosome organization] GO:0051301[cell division] GO:0051402[neuron apoptotic process] GO:0070419[nonhomologous end joining complex] GO:0071479[cellular response to ionizing radiation] GO:0071897[DNA biosynthetic process] GO:0075713[establishment of integrated proviral latency] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:2001252[positive regulation of chromosome organization]