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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Ral GTPase activating protein catalytic subunit alpha 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q13.2
Chromosome location (bp)
35538352 - 35809304
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6GYQ0 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0043547[positive regulation of GTPase activity] GO:0046982[protein heterodimerization activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0090630[activation of GTPase activity]
Q6GYQ0 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0043547[positive regulation of GTPase activity] GO:0046982[protein heterodimerization activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0090630[activation of GTPase activity]
Q6GYQ0 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0043547[positive regulation of GTPase activity] GO:0046982[protein heterodimerization activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0090630[activation of GTPase activity]
Q6GYQ0 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0043547[positive regulation of GTPase activity] GO:0046982[protein heterodimerization activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0090630[activation of GTPase activity]
H0YJB5 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction]
H0YJ04 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction]
A0A1B0GUI1 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction]
A0A7P0TAR5 [Direct mapping] Ral GTPase-activating protein subunit alpha-1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005634[nucleus] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction]
The Human Protein Atlas project is funded
