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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.1
Chromosome location (bp)
201464278 - 201469237
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9Y5J5 [Direct mapping] Pleckstrin homology-like domain family A member 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0009653[anatomical structure morphogenesis] GO:0010314[phosphatidylinositol-5-phosphate binding] GO:0016020[membrane] GO:0032266[phosphatidylinositol-3-phosphate binding] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043065[positive regulation of apoptotic process] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0051898[negative regulation of protein kinase B signaling] GO:0080025[phosphatidylinositol-3,5-bisphosphate binding] GO:1901981[phosphatidylinositol phosphate binding]
Q9Y5J5 [Direct mapping] Pleckstrin homology-like domain family A member 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0009653[anatomical structure morphogenesis] GO:0010314[phosphatidylinositol-5-phosphate binding] GO:0016020[membrane] GO:0032266[phosphatidylinositol-3-phosphate binding] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043065[positive regulation of apoptotic process] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0051898[negative regulation of protein kinase B signaling] GO:0080025[phosphatidylinositol-3,5-bisphosphate binding] GO:1901981[phosphatidylinositol phosphate binding]