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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.1
Chromosome location (bp)
18266260 - 18269977
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Keywords assigned by UniProt to proteins due to their particular molecular function.
Heparin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Acute phase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P0DJI8 [Direct mapping] Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001664[G protein-coupled receptor binding] GO:0001819[positive regulation of cytokine production] GO:0005576[extracellular region] GO:0005881[cytoplasmic microtubule] GO:0006953[acute-phase response] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0008201[heparin binding] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0032732[positive regulation of interleukin-1 production] GO:0034364[high-density lipoprotein particle] GO:0045785[positive regulation of cell adhesion] GO:0048246[macrophage chemotaxis] GO:0048247[lymphocyte chemotaxis] GO:0050708[regulation of protein secretion] GO:0050728[negative regulation of inflammatory response] GO:0070062[extracellular exosome] GO:0071682[endocytic vesicle lumen]
P0DJI8 [Direct mapping] Serum amyloid A-1 protein Amyloid protein A Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001664[G protein-coupled receptor binding] GO:0001819[positive regulation of cytokine production] GO:0005576[extracellular region] GO:0005881[cytoplasmic microtubule] GO:0006953[acute-phase response] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0008201[heparin binding] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0032732[positive regulation of interleukin-1 production] GO:0034364[high-density lipoprotein particle] GO:0045785[positive regulation of cell adhesion] GO:0048246[macrophage chemotaxis] GO:0048247[lymphocyte chemotaxis] GO:0050708[regulation of protein secretion] GO:0050728[negative regulation of inflammatory response] GO:0070062[extracellular exosome] GO:0071682[endocytic vesicle lumen]
The Human Protein Atlas project is funded
