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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.13
Chromosome location (bp)
125430358 - 125438403
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase 1. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain 2. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA 3. Binds selectively the recognition sequence of CEBPA 4. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity 5,6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004672[protein kinase activity] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0007254[JNK cascade] GO:0014912[negative regulation of smooth muscle cell migration] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032496[response to lipopolysaccharide] GO:0043405[regulation of MAP kinase activity] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045645[positive regulation of eosinophil differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045659[negative regulation of neutrophil differentiation] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0055106[ubiquitin-protein transferase regulator activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding]
Enzymes Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672[protein kinase activity] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0007254[JNK cascade] GO:0014912[negative regulation of smooth muscle cell migration] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032496[response to lipopolysaccharide] GO:0043405[regulation of MAP kinase activity] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0055106[ubiquitin-protein transferase regulator activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
