We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.2
Chromosome location (bp)
67266473 - 67286556
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them 1. Key regulator of LPAR1 signaling 2. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor 3. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner 4. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A0S2Z392 [Target identity:100%; Query identity:100%] G protein-coupled receptor kinase
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001664[G protein-coupled receptor binding] GO:0002026[regulation of the force of heart contraction] GO:0002029[desensitization of G protein-coupled receptor signaling pathway] GO:0003108[negative regulation of the force of heart contraction by chemical signal] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004703[G protein-coupled receptor kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005929[cilium] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007217[tachykinin receptor signaling pathway] GO:0007507[heart development] GO:0009966[regulation of signal transduction] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019079[viral genome replication] GO:0031623[receptor internalization] GO:0031694[alpha-2A adrenergic receptor binding] GO:0031755[Edg-2 lysophosphatidic acid receptor binding] GO:0033605[positive regulation of catecholamine secretion] GO:0042995[cell projection] GO:0045202[synapse] GO:0045988[negative regulation of striated muscle contraction] GO:0046718[viral entry into host cell] GO:0047696[beta-adrenergic receptor kinase activity] GO:0050896[response to stimulus] GO:0060048[cardiac muscle contraction] GO:0098793[presynapse] GO:0098794[postsynapse] GO:1901081[negative regulation of relaxation of smooth muscle]
The Human Protein Atlas project is funded
