GENERAL INFORMATIONi
Gene namei KAT5
Synonyms cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5
Gene descriptioni Lysine acetyltransferase 5
Protein classi Disease related genes
Enzymes
Human disease related genes
Metabolic proteins
Potential drug targets
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 11
Cytoband q13.1
Chromosome location (bp) 65711996 - 65719604
Number of transcriptsi 11
Ensembl ENSG00000172977 (version 109)
Entrez gene 10524
HGNC HGNC:5275
UniProt Q92993 (UniProt - Evidence at protein level)
neXtProt NX_Q92993
GeneCards KAT5
Antibodypedia KAT5 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription 14, 15, 16, 17, 18. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair 19, 20, 21. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks 22, 23. Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage 24, 25. The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome 26. Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39. Directly acetylates and activates ATM 40. Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex 41. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 42. Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity 43, 44. Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 45. Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity 46. Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer 47. Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation 48. Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 49. Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase 50. Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol 51. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively 52, 53. Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins 54, 55, 56, 57. Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis 58. Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes 59. Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment 60. Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis 61. show less
Molecular function (UniProt)i Activator, Acyltransferase, Chromatin regulator, Transferase
Biological process (UniProt)i DNA damage, DNA repair, Growth regulation, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
KAT5-201
ENSP00000340330
ENST00000341318
Q92993
[Direct mapping] Histone acetyltransferase KAT5
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000123 [histone acetyltransferase complex]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000786 [nucleosome]
GO:0000812 [Swr1 complex]
GO:0000922 [spindle pole]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003712 [transcription coregulator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006473 [protein acetylation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007286 [spermatid development]
GO:0010212 [response to ionizing radiation]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010508 [positive regulation of autophagy]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016740 [transferase activity]
GO:0016746 [acyltransferase activity]
GO:0018394 [peptidyl-lysine acetylation]
GO:0021915 [neural tube development]
GO:0022008 [neurogenesis]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035092 [sperm DNA condensation]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0042149 [cellular response to glucose starvation]
GO:0042393 [histone binding]
GO:0042753 [positive regulation of circadian rhythm]
GO:0042981 [regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0043998 [H2A histone acetyltransferase activity]
GO:0043999 [histone acetyltransferase activity (H2A-K5 specific)]
GO:0045087 [innate immune response]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051726 [regulation of cell cycle]
GO:0061733 [peptide-lysine-N-acetyltransferase activity]
GO:0062033 [positive regulation of mitotic sister chromatid segregation]
GO:0071333 [cellular response to glucose stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090398 [cellular senescence]
GO:0097431 [mitotic spindle pole]
GO:0106226 [peptide 2-hydroxyisobutyryltransferase activity]
GO:0140064 [peptide crotonyltransferase activity]
GO:0140065 [peptide butyryltransferase activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:0140861 [DNA repair-dependent chromatin remodeling]
GO:1901985 [positive regulation of protein acetylation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1905168 [positive regulation of double-strand break repair via homologous recombination]
GO:1905691 [lipid droplet disassembly]
GO:2000779 [regulation of double-strand break repair]
Show all
 546 aa
61.8 kDa 		No 0
KAT5-202
ENSP00000344955
ENST00000352980
Q92993
[Direct mapping] Histone acetyltransferase KAT5
Show all
A0A024R5E8
[Target identity:100%; Query identity:100%] Histone acetyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000123 [histone acetyltransferase complex]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000786 [nucleosome]
GO:0000812 [Swr1 complex]
GO:0000922 [spindle pole]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003712 [transcription coregulator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007286 [spermatid development]
GO:0010212 [response to ionizing radiation]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010508 [positive regulation of autophagy]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016740 [transferase activity]
GO:0016746 [acyltransferase activity]
GO:0018394 [peptidyl-lysine acetylation]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0042149 [cellular response to glucose starvation]
GO:0042393 [histone binding]
GO:0042753 [positive regulation of circadian rhythm]
GO:0042981 [regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0043998 [H2A histone acetyltransferase activity]
GO:0043999 [histone acetyltransferase activity (H2A-K5 specific)]
GO:0045087 [innate immune response]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051726 [regulation of cell cycle]
GO:0061733 [peptide-lysine-N-acetyltransferase activity]
GO:0062033 [positive regulation of mitotic sister chromatid segregation]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090398 [cellular senescence]
GO:0097431 [mitotic spindle pole]
GO:0106226 [peptide 2-hydroxyisobutyryltransferase activity]
GO:0140064 [peptide crotonyltransferase activity]
GO:0140065 [peptide butyryltransferase activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:0140861 [DNA repair-dependent chromatin remodeling]
GO:1901985 [positive regulation of protein acetylation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1905168 [positive regulation of double-strand break repair via homologous recombination]
GO:1905691 [lipid droplet disassembly]
GO:2000779 [regulation of double-strand break repair]
Show all
 461 aa
53.1 kDa 		No 0
KAT5-203
ENSP00000366245
ENST00000377046
Q92993
[Direct mapping] Histone acetyltransferase KAT5
Show all
A0A024R597
[Target identity:100%; Query identity:100%] Histone acetyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000123 [histone acetyltransferase complex]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000786 [nucleosome]
GO:0000812 [Swr1 complex]
GO:0000922 [spindle pole]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003712 [transcription coregulator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007286 [spermatid development]
GO:0010212 [response to ionizing radiation]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010508 [positive regulation of autophagy]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016740 [transferase activity]
GO:0016746 [acyltransferase activity]
GO:0018394 [peptidyl-lysine acetylation]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0042149 [cellular response to glucose starvation]
GO:0042393 [histone binding]
GO:0042753 [positive regulation of circadian rhythm]
GO:0042981 [regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0043998 [H2A histone acetyltransferase activity]
GO:0043999 [histone acetyltransferase activity (H2A-K5 specific)]
GO:0045087 [innate immune response]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051726 [regulation of cell cycle]
GO:0061733 [peptide-lysine-N-acetyltransferase activity]
GO:0062033 [positive regulation of mitotic sister chromatid segregation]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090398 [cellular senescence]
GO:0097431 [mitotic spindle pole]
GO:0106226 [peptide 2-hydroxyisobutyryltransferase activity]
GO:0140064 [peptide crotonyltransferase activity]
GO:0140065 [peptide butyryltransferase activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:0140861 [DNA repair-dependent chromatin remodeling]
GO:1901985 [positive regulation of protein acetylation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1905168 [positive regulation of double-strand break repair via homologous recombination]
GO:1905691 [lipid droplet disassembly]
GO:2000779 [regulation of double-strand break repair]
Show all
 513 aa
58.6 kDa 		No 0
KAT5-207
ENSP00000436000
ENST00000528198
E9PRM3
[Direct mapping] Histone acetyltransferase KAT5
Show all
Metabolic proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004402 [histone acetyltransferase activity]
GO:0010468 [regulation of gene expression]
GO:0016573 [histone acetylation]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0051171 [regulation of nitrogen compound metabolic process]
GO:0080090 [regulation of primary metabolic process]
Show all
 189 aa
21.3 kDa 		No 0
KAT5-208
ENSP00000434765
ENST00000530446
Q92993
[Direct mapping] Histone acetyltransferase KAT5
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000123 [histone acetyltransferase complex]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000786 [nucleosome]
GO:0000812 [Swr1 complex]
GO:0000922 [spindle pole]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003712 [transcription coregulator activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007286 [spermatid development]
GO:0010212 [response to ionizing radiation]
GO:0010485 [histone H4 acetyltransferase activity]
GO:0010508 [positive regulation of autophagy]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016740 [transferase activity]
GO:0016746 [acyltransferase activity]
GO:0018394 [peptidyl-lysine acetylation]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0042149 [cellular response to glucose starvation]
GO:0042393 [histone binding]
GO:0042753 [positive regulation of circadian rhythm]
GO:0042981 [regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0043998 [H2A histone acetyltransferase activity]
GO:0043999 [histone acetyltransferase activity (H2A-K5 specific)]
GO:0045087 [innate immune response]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051726 [regulation of cell cycle]
GO:0061733 [peptide-lysine-N-acetyltransferase activity]
GO:0062033 [positive regulation of mitotic sister chromatid segregation]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090398 [cellular senescence]
GO:0097431 [mitotic spindle pole]
GO:0106226 [peptide 2-hydroxyisobutyryltransferase activity]
GO:0140064 [peptide crotonyltransferase activity]
GO:0140065 [peptide butyryltransferase activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:0140861 [DNA repair-dependent chromatin remodeling]
GO:1901985 [positive regulation of protein acetylation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1905168 [positive regulation of double-strand break repair via homologous recombination]
GO:1905691 [lipid droplet disassembly]
GO:2000779 [regulation of double-strand break repair]
Show all
 494 aa
56.3 kDa 		No 0
KAT5-209
ENSP00000436247
ENST00000530605
H0YEP0
[Direct mapping] Histone acetyltransferase KAT5
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010468 [regulation of gene expression]
GO:0051171 [regulation of nitrogen compound metabolic process]
GO:0080090 [regulation of primary metabolic process]
Show all
 167 aa
18.5 kDa 		No 0
KAT5-210
ENSP00000436012
ENST00000531880
E9PRL6
[Direct mapping] Histone acetyltransferase KAT5
Show all
Metabolic proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0016573 [histone acetylation]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0045893 [positive regulation of DNA-templated transcription]
Show all
 269 aa
30 kDa 		No 0
KAT5-213
ENSP00000435766
ENST00000533596
H0YEG3
[Direct mapping] Histone acetyltransferase KAT5
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004402 [histone acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0035267 [NuA4 histone acetyltransferase complex]
Show all
 95 aa
10.9 kDa 		No 0
KAT5-214
ENSP00000435939
ENST00000534104
E9PRS1
[Direct mapping] Histone acetyltransferase KAT5
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
 16 aa
1.7 kDa 		No 0
KAT5-216
ENSP00000431819
ENST00000534650
E9PJI1
[Direct mapping] Histone acetyltransferase
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Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0016573 [histone acetylation]
GO:0016740 [transferase activity]
GO:0016746 [acyltransferase activity]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043231 [intracellular membrane-bounded organelle]
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 302 aa
35.4 kDa 		No 0
KAT5-217
ENSP00000434993
ENST00000534681
E9PMG8
[Direct mapping] Histone acetyltransferase KAT5
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Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
 45 aa
5.3 kDa 		No 0

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The Human Protein Atlas

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