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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q22.1
Chromosome location (bp)
103074881 - 103099759
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Growth regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:0040010[positive regulation of growth rate] GO:0043066[negative regulation of apoptotic process] GO:0050692[DNA binding domain binding] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q8N2F6 [Direct mapping] Armadillo repeat-containing protein 10
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0016020[membrane] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
The Human Protein Atlas project is funded
