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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.3
Chromosome location (bp)
70203296 - 70207390
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors1,2,3,4,5,6,7. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation 8,9,10,11,12. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis 13. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling 14....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13158 [Direct mapping] FAS-associated death domain protein
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001822[kidney development] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002020[protease binding] GO:0002376[immune system process] GO:0002821[positive regulation of adaptive immune response] GO:0005123[death receptor binding] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032729[positive regulation of interferon-gamma production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032813[tumor necrosis factor receptor superfamily binding] GO:0032991[protein-containing complex] GO:0033077[T cell differentiation in thymus] GO:0033612[receptor serine/threonine kinase binding] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042104[positive regulation of activated T cell proliferation] GO:0042220[response to cocaine] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043005[neuron projection] GO:0043029[T cell homeostasis] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043278[response to morphine] GO:0044297[cell body] GO:0044877[protein-containing complex binding] GO:0045087[innate immune response] GO:0045121[membrane raft] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048148[behavioral response to cocaine] GO:0048535[lymph node development] GO:0048536[spleen development] GO:0048538[thymus development] GO:0051607[defense response to virus] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0070236[negative regulation of activation-induced cell death of T cells] GO:0071260[cellular response to mechanical stimulus] GO:0071550[death-inducing signaling complex assembly] GO:0089720[caspase binding] GO:0097049[motor neuron apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097342[ripoptosome] GO:0097527[necroptotic signaling pathway] GO:2000454[positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation] GO:2001238[positive regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
