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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.3
Chromosome location (bp)
1420689 - 1463162
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764[neuron migration] GO:0001784[phosphotyrosine residue binding] GO:0001878[response to yeast] GO:0002685[regulation of leukocyte migration] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0008092[cytoskeletal protein binding] GO:0008283[cell population proliferation] GO:0008360[regulation of cell shape] GO:0009966[regulation of signal transduction] GO:0014911[positive regulation of smooth muscle cell migration] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0016358[dendrite development] GO:0016477[cell migration] GO:0017124[SH3 domain binding] GO:0019899[enzyme binding] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0021766[hippocampus development] GO:0021987[cerebral cortex development] GO:0030010[establishment of cell polarity] GO:0030036[actin cytoskeleton organization] GO:0030159[signaling receptor complex adaptor activity] GO:0030674[protein-macromolecule adaptor activity] GO:0030971[receptor tyrosine kinase binding] GO:0031594[neuromuscular junction] GO:0031625[ubiquitin protein ligase binding] GO:0032956[regulation of actin cytoskeleton organization] GO:0032991[protein-containing complex] GO:0033628[regulation of cell adhesion mediated by integrin] GO:0035020[regulation of Rac protein signal transduction] GO:0035591[signaling adaptor activity] GO:0035685[helper T cell diapedesis] GO:0035728[response to hepatocyte growth factor] GO:0038026[reelin-mediated signaling pathway] GO:0042169[SH2 domain binding] GO:0042542[response to hydrogen peroxide] GO:0043087[regulation of GTPase activity] GO:0043393[regulation of protein binding] GO:0043621[protein self-association] GO:0045121[membrane raft] GO:0045309[protein phosphorylated amino acid binding] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046330[positive regulation of JNK cascade] GO:0046875[ephrin receptor binding] GO:0048013[ephrin receptor signaling pathway] GO:0050773[regulation of dendrite development] GO:0060090[molecular adaptor activity] GO:0060326[cell chemotaxis] GO:0061045[negative regulation of wound healing] GO:0061847[response to cholecystokinin] GO:0070062[extracellular exosome] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0071732[cellular response to nitric oxide] GO:0072657[protein localization to membrane] GO:0090630[activation of GTPase activity] GO:0097110[scaffold protein binding] GO:0098698[postsynaptic specialization assembly] GO:0098749[cerebellar neuron development] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901652[response to peptide] GO:1902531[regulation of intracellular signal transduction] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990314[cellular response to insulin-like growth factor stimulus] GO:1990782[protein tyrosine kinase binding] GO:1990859[cellular response to endothelin] GO:2000146[negative regulation of cell motility] GO:2000404[regulation of T cell migration]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)