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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q22.1
Chromosome location (bp)
68827531 - 68895432
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta 1. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005938[cell cortex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010821[regulation of mitochondrion organization] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0045787[positive regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048839[inner ear development] GO:0051301[cell division] GO:0051881[regulation of mitochondrial membrane potential] GO:0051897[positive regulation of protein kinase B signaling] GO:0061418[regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500[cellular response to nitrosative stress] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901858[regulation of mitochondrial DNA metabolic process] GO:1902882[regulation of response to oxidative stress] GO:1904031[positive regulation of cyclin-dependent protein kinase activity] GO:1904120[positive regulation of otic vesicle morphogenesis]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010821[regulation of mitochondrion organization] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051301[cell division] GO:0051881[regulation of mitochondrial membrane potential] GO:0061418[regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500[cellular response to nitrosative stress] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901858[regulation of mitochondrial DNA metabolic process] GO:1902882[regulation of response to oxidative stress] GO:1904031[positive regulation of cyclin-dependent protein kinase activity]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010821[regulation of mitochondrion organization] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051301[cell division] GO:0051881[regulation of mitochondrial membrane potential] GO:0061418[regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500[cellular response to nitrosative stress] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901858[regulation of mitochondrial DNA metabolic process] GO:1902882[regulation of response to oxidative stress] GO:1904031[positive regulation of cyclin-dependent protein kinase activity]
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010821[regulation of mitochondrion organization] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051301[cell division] GO:0051881[regulation of mitochondrial membrane potential] GO:0061418[regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500[cellular response to nitrosative stress] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901858[regulation of mitochondrial DNA metabolic process] GO:1902882[regulation of response to oxidative stress] GO:1904031[positive regulation of cyclin-dependent protein kinase activity]
The Human Protein Atlas project is funded
