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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.1
Chromosome location (bp)
84139482 - 84154841
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport 1,2,3,4. Mediates proton-dependent calcium efflux from mitochondrion 5,6. Functions also as an electroneutral mitochondrial proton/potassium exchanger 7. Required for the mitochondrial tubular network and cristae organization 8,9,10. Involved in apoptotic release of cytochrome c 11. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria 12. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome 13....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Involved in inner mitochondrial membrane organization and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Q9H3K2 [Direct mapping] Growth hormone-inducible transmembrane protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0006915[apoptotic process] GO:0007007[inner mitochondrial membrane organization] GO:0016020[membrane] GO:0070062[extracellular exosome] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
The Human Protein Atlas project is funded
