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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p22
Chromosome location (bp)
13083361 - 13604610
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 1. The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]
Q96QB1 [Direct mapping] Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843[neural tube closure] GO:0003007[heart morphogenesis] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165[signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0021575[hindbrain morphogenesis] GO:0030036[actin cytoskeleton organization] GO:0030336[negative regulation of cell migration] GO:0030864[cortical actin cytoskeleton] GO:0030900[forebrain development] GO:0032587[ruffle membrane] GO:0032956[regulation of actin cytoskeleton organization] GO:0035023[regulation of Rho protein signal transduction] GO:0035024[negative regulation of Rho protein signal transduction] GO:0035307[positive regulation of protein dephosphorylation] GO:0042169[SH2 domain binding] GO:0045121[membrane raft] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly] GO:0070161[anchoring junction] GO:1900119[positive regulation of execution phase of apoptosis]