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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q21.23
Chromosome location (bp)
84491985 - 84499292
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001764[neuron migration] GO:0003309[type B pancreatic cell differentiation] GO:0003310[pancreatic A cell differentiation] GO:0003323[type B pancreatic cell development] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007224[smoothened signaling pathway] GO:0008283[cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009887[animal organ morphogenesis] GO:0021953[central nervous system neuron differentiation] GO:0022008[neurogenesis] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030516[regulation of axon extension] GO:0031016[pancreas development] GO:0031018[endocrine pancreas development] GO:0032024[positive regulation of insulin secretion] GO:0035094[response to nicotine] GO:0043565[sequence-specific DNA binding] GO:0044342[type B pancreatic cell proliferation] GO:0045666[positive regulation of neuron differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048709[oligodendrocyte differentiation] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0048715[negative regulation of oligodendrocyte differentiation] GO:0050796[regulation of insulin secretion] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051594[detection of glucose] GO:0070062[extracellular exosome] GO:0071345[cellular response to cytokine stimulus] GO:0071375[cellular response to peptide hormone stimulus] GO:0072560[type B pancreatic cell maturation] GO:2000078[positive regulation of type B pancreatic cell development] GO:2001222[regulation of neuron migration]
The Human Protein Atlas project is funded
