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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p13.1
Chromosome location (bp)
116372668 - 116410261
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Translocase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Adrenal gland diseases Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002026[regulation of the force of heart contraction] GO:0002028[regulation of sodium ion transport] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008217[regulation of blood pressure] GO:0008556[P-type potassium transmembrane transporter activity] GO:0009410[response to xenobiotic stimulus] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0016791[phosphatase activity] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030315[T-tubule] GO:0030424[axon] GO:0030955[potassium ion binding] GO:0031090[organelle membrane] GO:0031402[sodium ion binding] GO:0031947[negative regulation of glucocorticoid biosynthetic process] GO:0032991[protein-containing complex] GO:0034220[ion transmembrane transport] GO:0036126[sperm flagellum] GO:0036376[sodium ion export across plasma membrane] GO:0042383[sarcolemma] GO:0042470[melanosome] GO:0042995[cell projection] GO:0045121[membrane raft] GO:0045822[negative regulation of heart contraction] GO:0045823[positive regulation of heart contraction] GO:0045989[positive regulation of striated muscle contraction] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0051087[chaperone binding] GO:0055119[relaxation of cardiac muscle] GO:0060047[heart contraction] GO:0060342[photoreceptor inner segment membrane] GO:0070062[extracellular exosome] GO:0071383[cellular response to steroid hormone stimulus] GO:0086002[cardiac muscle cell action potential involved in contraction] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1990239[steroid hormone binding] GO:1990573[potassium ion import across plasma membrane]
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Adrenal gland diseases Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002028[regulation of sodium ion transport] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008556[P-type potassium transmembrane transporter activity] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030315[T-tubule] GO:0030424[axon] GO:0030955[potassium ion binding] GO:0031090[organelle membrane] GO:0031402[sodium ion binding] GO:0032991[protein-containing complex] GO:0034220[ion transmembrane transport] GO:0036126[sperm flagellum] GO:0036376[sodium ion export across plasma membrane] GO:0042383[sarcolemma] GO:0042470[melanosome] GO:0042995[cell projection] GO:0045121[membrane raft] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0051087[chaperone binding] GO:0055119[relaxation of cardiac muscle] GO:0060342[photoreceptor inner segment membrane] GO:0070062[extracellular exosome] GO:0071383[cellular response to steroid hormone stimulus] GO:0086002[cardiac muscle cell action potential involved in contraction] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1990239[steroid hormone binding] GO:1990573[potassium ion import across plasma membrane]
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Adrenal gland diseases Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0002028[regulation of sodium ion transport] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008556[P-type potassium transmembrane transporter activity] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030315[T-tubule] GO:0030424[axon] GO:0030955[potassium ion binding] GO:0031090[organelle membrane] GO:0031402[sodium ion binding] GO:0032991[protein-containing complex] GO:0034220[ion transmembrane transport] GO:0036126[sperm flagellum] GO:0036376[sodium ion export across plasma membrane] GO:0042383[sarcolemma] GO:0042470[melanosome] GO:0042995[cell projection] GO:0045121[membrane raft] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0051087[chaperone binding] GO:0055119[relaxation of cardiac muscle] GO:0060342[photoreceptor inner segment membrane] GO:0070062[extracellular exosome] GO:0071383[cellular response to steroid hormone stimulus] GO:0086002[cardiac muscle cell action potential involved in contraction] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1990239[steroid hormone binding] GO:1990573[potassium ion import across plasma membrane]