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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q12.3
Chromosome location (bp)
62676498 - 62679117
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling 1. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 2. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B 3. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer 4. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q04323 [Direct mapping] UBX domain-containing protein 1
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A0A024R539 [Target identity:100%; Query identity:100%] Uncharacterized protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0031397[negative regulation of protein ubiquitination] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034098[VCP-NPL4-UFD1 AAA ATPase complex] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051117[ATPase binding] GO:0071796[K6-linked polyubiquitin modification-dependent protein binding] GO:1903094[negative regulation of protein K48-linked deubiquitination] GO:1904293[negative regulation of ERAD pathway] GO:1904855[proteasome regulatory particle binding] GO:2000157[negative regulation of ubiquitin-specific protease activity]
Q04323 [Direct mapping] UBX domain-containing protein 1
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A0A024R598 [Target identity:100%; Query identity:100%] Uncharacterized protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0031397[negative regulation of protein ubiquitination] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034098[VCP-NPL4-UFD1 AAA ATPase complex] GO:0036435[K48-linked polyubiquitin modification-dependent protein binding] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051117[ATPase binding] GO:0071796[K6-linked polyubiquitin modification-dependent protein binding] GO:1903094[negative regulation of protein K48-linked deubiquitination] GO:1904293[negative regulation of ERAD pathway] GO:1904855[proteasome regulatory particle binding] GO:2000157[negative regulation of ubiquitin-specific protease activity]
The Human Protein Atlas project is funded
