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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.2
Chromosome location (bp)
4630919 - 4642294
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators 1,2,3,4,5,6. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE 7,8,9,10. It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE 11. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets 12. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides 13. Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 14....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Dioxygenase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Fatty acid metabolism, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Iron, Lipid-binding, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001503[ossification] GO:0001676[long-chain fatty acid metabolic process] GO:0002820[negative regulation of adaptive immune response] GO:0004052[arachidonate 12(S)-lipoxygenase activity] GO:0005506[iron ion binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006646[phosphatidylethanolamine biosynthetic process] GO:0006690[icosanoid metabolic process] GO:0006954[inflammatory response] GO:0008289[lipid binding] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019395[fatty acid oxidation] GO:0030282[bone mineralization] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034440[lipid oxidation] GO:0034976[response to endoplasmic reticulum stress] GO:0035358[regulation of peroxisome proliferator activated receptor signaling pathway] GO:0035963[cellular response to interleukin-13] GO:0042060[wound healing] GO:0042759[long-chain fatty acid biosynthetic process] GO:0043277[apoptotic cell clearance] GO:0043651[linoleic acid metabolic process] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0050727[regulation of inflammatory response] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071277[cellular response to calcium ion] GO:1901074[regulation of engulfment of apoptotic cell] GO:2001303[lipoxin A4 biosynthetic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503[ossification] GO:0001676[long-chain fatty acid metabolic process] GO:0002820[negative regulation of adaptive immune response] GO:0004052[arachidonate 12(S)-lipoxygenase activity] GO:0005506[iron ion binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006646[phosphatidylethanolamine biosynthetic process] GO:0006690[icosanoid metabolic process] GO:0006954[inflammatory response] GO:0008289[lipid binding] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019395[fatty acid oxidation] GO:0030282[bone mineralization] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034440[lipid oxidation] GO:0034976[response to endoplasmic reticulum stress] GO:0035358[regulation of peroxisome proliferator activated receptor signaling pathway] GO:0035963[cellular response to interleukin-13] GO:0042060[wound healing] GO:0042759[long-chain fatty acid biosynthetic process] GO:0043277[apoptotic cell clearance] GO:0043651[linoleic acid metabolic process] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0050727[regulation of inflammatory response] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071277[cellular response to calcium ion] GO:1901074[regulation of engulfment of apoptotic cell] GO:2001303[lipoxin A4 biosynthetic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503[ossification] GO:0001676[long-chain fatty acid metabolic process] GO:0002820[negative regulation of adaptive immune response] GO:0004052[arachidonate 12(S)-lipoxygenase activity] GO:0005506[iron ion binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006646[phosphatidylethanolamine biosynthetic process] GO:0006690[icosanoid metabolic process] GO:0006954[inflammatory response] GO:0008289[lipid binding] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019395[fatty acid oxidation] GO:0030282[bone mineralization] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034440[lipid oxidation] GO:0034976[response to endoplasmic reticulum stress] GO:0035358[regulation of peroxisome proliferator activated receptor signaling pathway] GO:0035963[cellular response to interleukin-13] GO:0042060[wound healing] GO:0042759[long-chain fatty acid biosynthetic process] GO:0043277[apoptotic cell clearance] GO:0043651[linoleic acid metabolic process] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0050727[regulation of inflammatory response] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071277[cellular response to calcium ion] GO:1901074[regulation of engulfment of apoptotic cell] GO:2001303[lipoxin A4 biosynthetic process]
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