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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q21.3
Chromosome location (bp)
155002630 - 155018523
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes 1. Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001217[DNA-binding transcription repressor activity] GO:0001865[NK T cell differentiation] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007398[ectoderm development] GO:0007595[lactation] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0032740[positive regulation of interleukin-17 production] GO:0032868[response to insulin] GO:0042803[protein homodimerization activity] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0051141[negative regulation of NK T cell proliferation] GO:0090336[positive regulation of brown fat cell differentiation] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990845[adaptive thermogenesis] GO:2000640[positive regulation of SREBP signaling pathway]
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001217[DNA-binding transcription repressor activity] GO:0001865[NK T cell differentiation] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007398[ectoderm development] GO:0007595[lactation] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0032740[positive regulation of interleukin-17 production] GO:0032868[response to insulin] GO:0042803[protein homodimerization activity] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0051141[negative regulation of NK T cell proliferation] GO:0090336[positive regulation of brown fat cell differentiation] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990845[adaptive thermogenesis] GO:2000640[positive regulation of SREBP signaling pathway]
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001217[DNA-binding transcription repressor activity] GO:0001865[NK T cell differentiation] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007398[ectoderm development] GO:0007595[lactation] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0032740[positive regulation of interleukin-17 production] GO:0032868[response to insulin] GO:0042803[protein homodimerization activity] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0051141[negative regulation of NK T cell proliferation] GO:0090336[positive regulation of brown fat cell differentiation] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990845[adaptive thermogenesis] GO:2000640[positive regulation of SREBP signaling pathway]
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001217[DNA-binding transcription repressor activity] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001865[NK T cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007398[ectoderm development] GO:0007595[lactation] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0030154[cell differentiation] GO:0032740[positive regulation of interleukin-17 production] GO:0032868[response to insulin] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043376[regulation of CD8-positive, alpha-beta T cell differentiation] GO:0043377[negative regulation of CD8-positive, alpha-beta T cell differentiation] GO:0045622[regulation of T-helper cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0051141[negative regulation of NK T cell proliferation] GO:0090336[positive regulation of brown fat cell differentiation] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990845[adaptive thermogenesis] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000640[positive regulation of SREBP signaling pathway]
The Human Protein Atlas project is funded
