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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p16.3
Chromosome location (bp)
1211445 - 1250333
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NAD
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13363 [Direct mapping] C-terminal-binding protein 1
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X5D8Y5 [Target identity:100%; Query identity:100%] C-terminal binding protein 1 isoform C
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008022[protein C-terminus binding] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019904[protein domain specific binding] GO:0030154[cell differentiation] GO:0031065[positive regulation of histone deacetylation] GO:0031507[heterochromatin formation] GO:0035067[negative regulation of histone acetylation] GO:0042802[identical protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0051726[regulation of cell cycle] GO:0090241[negative regulation of histone H4 acetylation] GO:0140297[DNA-binding transcription factor binding]
Q13363 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001221[transcription coregulator binding] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0008022[protein C-terminus binding] GO:0008285[negative regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0017053[transcription repressor complex] GO:0019079[viral genome replication] GO:0019904[protein domain specific binding] GO:0030154[cell differentiation] GO:0031065[positive regulation of histone deacetylation] GO:0031507[heterochromatin formation] GO:0035067[negative regulation of histone acetylation] GO:0042802[identical protein binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0048488[synaptic vesicle endocytosis] GO:0050872[white fat cell differentiation] GO:0051287[NAD binding] GO:0051726[regulation of cell cycle] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090241[negative regulation of histone H4 acetylation] GO:0097091[synaptic vesicle clustering] GO:0098831[presynaptic active zone cytoplasmic component] GO:0098978[glutamatergic synapse] GO:0098982[GABA-ergic synapse] GO:0140297[DNA-binding transcription factor binding]
H0Y8U5 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0003714[transcription corepressor activity] GO:0005654[nucleoplasm] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
H0Y8W7 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0005654[nucleoplasm] GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
H0Y913 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
D6RAX2 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0016491[oxidoreductase activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
E7EUB3 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
E9PGB1 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
E7ESU7 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
A0A0D9SGE6 [Direct mapping] C-terminal-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714[transcription corepressor activity] GO:0016616[oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287[NAD binding]
The Human Protein Atlas project is funded
