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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
G-protein coupled receptors Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.1
Chromosome location (bp)
202033855 - 202038441
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses 1. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0004888[transmembrane signaling receptor activity] GO:0004930[G protein-coupled receptor activity] GO:0005109[frizzled binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005768[endosome] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0010008[endosome membrane] GO:0010812[negative regulation of cell-substrate adhesion] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016055[Wnt signaling pathway] GO:0017147[Wnt-protein binding] GO:0019827[stem cell population maintenance] GO:0030165[PDZ domain binding] GO:0030182[neuron differentiation] GO:0033077[T cell differentiation in thymus] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035567[non-canonical Wnt signaling pathway] GO:0038031[non-canonical Wnt signaling pathway via JNK cascade] GO:0042327[positive regulation of phosphorylation] GO:0042666[negative regulation of ectodermal cell fate specification] GO:0042813[Wnt receptor activity] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0046330[positive regulation of JNK cascade] GO:0048103[somatic stem cell division] GO:0055038[recycling endosome membrane] GO:0060054[positive regulation of epithelial cell proliferation involved in wound healing] GO:0060070[canonical Wnt signaling pathway] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0060231[mesenchymal to epithelial transition] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0071300[cellular response to retinoic acid] GO:2000726[negative regulation of cardiac muscle cell differentiation]
The Human Protein Atlas project is funded
