GENERAL INFORMATIONi
Gene namei RPS3
Synonyms FLJ26283, FLJ27450, MGC87870, S3
Gene descriptioni Ribosomal protein S3
Protein classi Cancer-related genes
Enzymes
Plasma proteins
Ribosomal proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 11
Cytoband q13.4
Chromosome location (bp) 75399515 - 75422280
Number of transcriptsi 11
Ensembl ENSG00000149273 (version 109)
Entrez gene 6188
HGNC HGNC:10420
UniProt P23396 (UniProt - Evidence at protein level)
neXtProt NX_P23396
GeneCards RPS3
Antibodypedia RPS3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Component of the small ribosomal subunit 1, 2. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell 3, 4. Has endonuclease activity and plays a role in repair of damaged DNA 5. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA 6. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) 7. Has also been shown to bind with similar affinity to intact and damaged DNA 8. Stimulates the N-glycosylase activity of the base excision protein OGG1 9. Enhances the uracil excision activity of UNG1 10. Also stimulates the cleavage of the phosphodiester backbone by APEX1 11. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage 12. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide 13. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes 14. Represses its own translation by binding to its cognate mRNA 15. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination 16. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization 17. Involved in induction of apoptosis through its role in activation of CASP8 18. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 19. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation 20. show less
Molecular function (UniProt)i DNA-binding, Lyase, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological process (UniProt)i Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation, Translation regulation
Gene summary (Entrez)i Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
RPS3-201
ENSP00000278572
ENST00000278572
P23396
[Direct mapping] 40S ribosomal protein S3
Show all
Enzymes
   ENZYME proteins
   Lyases
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0003906 [DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005844 [polysome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0008017 [microtubule binding]
GO:0010628 [positive regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017148 [negative regulation of translation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0022626 [cytosolic ribosome]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030544 [Hsp70 protein binding]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032357 [oxidized purine DNA binding]
GO:0032358 [oxidized pyrimidine DNA binding]
GO:0032587 [ruffle membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045738 [negative regulation of DNA repair]
GO:0045739 [positive regulation of DNA repair]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0051536 [iron-sulfur cluster binding]
GO:0051879 [Hsp90 protein binding]
GO:0061481 [response to TNF agonist]
GO:0070062 [extracellular exosome]
GO:0070181 [small ribosomal subunit rRNA binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071159 [NF-kappaB complex]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072686 [mitotic spindle]
GO:0097100 [supercoiled DNA binding]
GO:0140078 [class I DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:1902546 [positive regulation of DNA N-glycosylase activity]
GO:1905053 [positive regulation of base-excision repair]
GO:1990904 [ribonucleoprotein complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 259 aa
28.5 kDa 		No 0
RPS3-202
ENSP00000416745
ENST00000422465
E9PSF4
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:1990904 [ribonucleoprotein complex]
Show all
 103 aa
11.2 kDa 		No 0
RPS3-203
ENSP00000433821
ENST00000524851
P23396
[Direct mapping] 40S ribosomal protein S3
Show all
Enzymes
   ENZYME proteins
   Lyases
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0003906 [DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005844 [polysome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0008017 [microtubule binding]
GO:0010628 [positive regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017148 [negative regulation of translation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0022626 [cytosolic ribosome]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030544 [Hsp70 protein binding]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032357 [oxidized purine DNA binding]
GO:0032358 [oxidized pyrimidine DNA binding]
GO:0032587 [ruffle membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045738 [negative regulation of DNA repair]
GO:0045739 [positive regulation of DNA repair]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0051536 [iron-sulfur cluster binding]
GO:0051879 [Hsp90 protein binding]
GO:0061481 [response to TNF agonist]
GO:0070062 [extracellular exosome]
GO:0070181 [small ribosomal subunit rRNA binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071159 [NF-kappaB complex]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072686 [mitotic spindle]
GO:0097100 [supercoiled DNA binding]
GO:0140078 [class I DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:1902546 [positive regulation of DNA N-glycosylase activity]
GO:1905053 [positive regulation of base-excision repair]
GO:1990904 [ribonucleoprotein complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 243 aa
26.7 kDa 		No 0
RPS3-205
ENSP00000436556
ENST00000525933
H0YEU2
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:1990904 [ribonucleoprotein complex]
Show all
 171 aa
18.6 kDa 		No 0
RPS3-207
ENSP00000433421
ENST00000526608
E9PL09
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005743 [mitochondrial inner membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006281 [DNA repair]
GO:0006412 [translation]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0051301 [cell division]
GO:0140078 [class I DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:1990904 [ribonucleoprotein complex]
Show all
 231 aa
25.4 kDa 		No 0
RPS3-208
ENSP00000435457
ENST00000527273
E9PK82
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005743 [mitochondrial inner membrane]
GO:0016020 [membrane]
Show all
 128 aa
14.3 kDa 		No 0
RPS3-209
ENSP00000436971
ENST00000527446
P23396
[Direct mapping] 40S ribosomal protein S3
Show all
Enzymes
   ENZYME proteins
   Lyases
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0003906 [DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005844 [polysome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0008017 [microtubule binding]
GO:0010628 [positive regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017148 [negative regulation of translation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0022626 [cytosolic ribosome]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030544 [Hsp70 protein binding]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032357 [oxidized purine DNA binding]
GO:0032358 [oxidized pyrimidine DNA binding]
GO:0032587 [ruffle membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045738 [negative regulation of DNA repair]
GO:0045739 [positive regulation of DNA repair]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0051536 [iron-sulfur cluster binding]
GO:0051879 [Hsp90 protein binding]
GO:0061481 [response to TNF agonist]
GO:0070062 [extracellular exosome]
GO:0070181 [small ribosomal subunit rRNA binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071159 [NF-kappaB complex]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072686 [mitotic spindle]
GO:0097100 [supercoiled DNA binding]
GO:0140078 [class I DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:1902546 [positive regulation of DNA N-glycosylase activity]
GO:1905053 [positive regulation of base-excision repair]
GO:1990904 [ribonucleoprotein complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 243 aa
26.7 kDa 		No 0
RPS3-211
ENSP00000435566
ENST00000528847
E9PJN9
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005730 [nucleolus]
GO:0005840 [ribosome]
GO:0006396 [RNA processing]
GO:0006412 [translation]
GO:1990904 [ribonucleoprotein complex]
Show all
 36 aa
3.8 kDa 		No 0
RPS3-214
ENSP00000433155
ENST00000530164
F2Z2S8
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005840 [ribosome]
GO:0016020 [membrane]
GO:1990904 [ribonucleoprotein complex]
Show all
 117 aa
13.1 kDa 		No 0
RPS3-217
ENSP00000434643
ENST00000531188
P23396
[Direct mapping] 40S ribosomal protein S3
Show all
Enzymes
   ENZYME proteins
   Lyases
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0003906 [DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005844 [polysome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0008017 [microtubule binding]
GO:0010628 [positive regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016829 [lyase activity]
GO:0017148 [negative regulation of translation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0022626 [cytosolic ribosome]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030544 [Hsp70 protein binding]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032357 [oxidized purine DNA binding]
GO:0032358 [oxidized pyrimidine DNA binding]
GO:0032587 [ruffle membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045738 [negative regulation of DNA repair]
GO:0045739 [positive regulation of DNA repair]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051225 [spindle assembly]
GO:0051301 [cell division]
GO:0051536 [iron-sulfur cluster binding]
GO:0051879 [Hsp90 protein binding]
GO:0061481 [response to TNF agonist]
GO:0070062 [extracellular exosome]
GO:0070181 [small ribosomal subunit rRNA binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071159 [NF-kappaB complex]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072686 [mitotic spindle]
GO:0097100 [supercoiled DNA binding]
GO:0140078 [class I DNA-(apurinic or apyrimidinic site) endonuclease activity]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:1902546 [positive regulation of DNA N-glycosylase activity]
GO:1905053 [positive regulation of base-excision repair]
GO:1990904 [ribonucleoprotein complex]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 243 aa
26.7 kDa 		No 0
RPS3-219
ENSP00000436335
ENST00000534440
E9PPU1
[Direct mapping] 40S ribosomal protein S3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0016020 [membrane]
Show all
 158 aa
17.4 kDa 		No 0

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