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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p11.2
Chromosome location (bp)
55019017 - 55211628
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses 1,2,3,4. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF 5,6,7,8,9,10,11,12,13. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules 14. May also activate the NF-kappa-B signaling cascade 15. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling 16. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin 17. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration 18. Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0000902[cell morphogenesis] GO:0001503[ossification] GO:0001618[virus receptor activity] GO:0001892[embryonic placenta development] GO:0001934[positive regulation of protein phosphorylation] GO:0001942[hair follicle development] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0004672[protein kinase activity] GO:0004709[MAP kinase kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005006[epidermal growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007435[salivary gland morphogenesis] GO:0007611[learning or memory] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008544[epidermis development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010008[endosome membrane] GO:0010750[positive regulation of nitric oxide mediated signal transduction] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019900[kinase binding] GO:0019903[protein phosphatase binding] GO:0021795[cerebral cortex cell migration] GO:0022008[neurogenesis] GO:0030054[cell junction] GO:0030139[endocytic vesicle] GO:0030235[nitric-oxide synthase regulator activity] GO:0030296[protein tyrosine kinase activator activity] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031901[early endosome membrane] GO:0031965[nuclear membrane] GO:0032587[ruffle membrane] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0034614[cellular response to reactive oxygen species] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042177[negative regulation of protein catabolic process] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0045121[membrane raft] GO:0045296[cadherin binding] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739[positive regulation of DNA repair] GO:0045740[positive regulation of DNA replication] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046328[regulation of JNK cascade] GO:0046718[viral entry into host cell] GO:0046777[protein autophosphorylation] GO:0048146[positive regulation of fibroblast proliferation] GO:0048408[epidermal growth factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0048546[digestive tract morphogenesis] GO:0050673[epithelial cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050999[regulation of nitric-oxide synthase activity] GO:0051015[actin filament binding] GO:0051117[ATPase binding] GO:0051205[protein insertion into membrane] GO:0051897[positive regulation of protein kinase B signaling] GO:0060571[morphogenesis of an epithelial fold] GO:0061029[eyelid development in camera-type eye] GO:0070141[response to UV-A] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071230[cellular response to amino acid stimulus] GO:0071276[cellular response to cadmium ion] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097489[multivesicular body, internal vesicle lumen] GO:0097708[intracellular vesicle] GO:0098590[plasma membrane region] GO:0098609[cell-cell adhesion] GO:0140677[molecular function activator activity] GO:1900020[positive regulation of protein kinase C activity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902895[positive regulation of miRNA transcription] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905208[negative regulation of cardiocyte differentiation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001503[ossification] GO:0001618[virus receptor activity] GO:0001934[positive regulation of protein phosphorylation] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0004672[protein kinase activity] GO:0004709[MAP kinase kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005006[epidermal growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007611[learning or memory] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010008[endosome membrane] GO:0010750[positive regulation of nitric oxide mediated signal transduction] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019900[kinase binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030054[cell junction] GO:0030235[nitric-oxide synthase regulator activity] GO:0030296[protein tyrosine kinase activator activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031901[early endosome membrane] GO:0031965[nuclear membrane] GO:0032587[ruffle membrane] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0034614[cellular response to reactive oxygen species] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042177[negative regulation of protein catabolic process] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0045121[membrane raft] GO:0045296[cadherin binding] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739[positive regulation of DNA repair] GO:0045740[positive regulation of DNA replication] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046328[regulation of JNK cascade] GO:0046718[viral entry into host cell] GO:0046777[protein autophosphorylation] GO:0048408[epidermal growth factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050999[regulation of nitric-oxide synthase activity] GO:0051015[actin filament binding] GO:0051117[ATPase binding] GO:0051205[protein insertion into membrane] GO:0051897[positive regulation of protein kinase B signaling] GO:0070141[response to UV-A] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071276[cellular response to cadmium ion] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097489[multivesicular body, internal vesicle lumen] GO:0097708[intracellular vesicle] GO:0098590[plasma membrane region] GO:0098609[cell-cell adhesion] GO:1900020[positive regulation of protein kinase C activity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902895[positive regulation of miRNA transcription] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905208[negative regulation of cardiocyte differentiation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001503[ossification] GO:0001618[virus receptor activity] GO:0001934[positive regulation of protein phosphorylation] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0004672[protein kinase activity] GO:0004709[MAP kinase kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005006[epidermal growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007611[learning or memory] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010008[endosome membrane] GO:0010750[positive regulation of nitric oxide mediated signal transduction] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019900[kinase binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030054[cell junction] GO:0030235[nitric-oxide synthase regulator activity] GO:0030296[protein tyrosine kinase activator activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031901[early endosome membrane] GO:0031965[nuclear membrane] GO:0032587[ruffle membrane] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0034614[cellular response to reactive oxygen species] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042177[negative regulation of protein catabolic process] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0045121[membrane raft] GO:0045296[cadherin binding] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739[positive regulation of DNA repair] GO:0045740[positive regulation of DNA replication] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046328[regulation of JNK cascade] GO:0046718[viral entry into host cell] GO:0046777[protein autophosphorylation] GO:0048408[epidermal growth factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050999[regulation of nitric-oxide synthase activity] GO:0051015[actin filament binding] GO:0051117[ATPase binding] GO:0051205[protein insertion into membrane] GO:0051897[positive regulation of protein kinase B signaling] GO:0070141[response to UV-A] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071276[cellular response to cadmium ion] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097489[multivesicular body, internal vesicle lumen] GO:0097708[intracellular vesicle] GO:0098590[plasma membrane region] GO:0098609[cell-cell adhesion] GO:1900020[positive regulation of protein kinase C activity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902895[positive regulation of miRNA transcription] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905208[negative regulation of cardiocyte differentiation]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001503[ossification] GO:0001618[virus receptor activity] GO:0001934[positive regulation of protein phosphorylation] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0004672[protein kinase activity] GO:0004709[MAP kinase kinase kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0004888[transmembrane signaling receptor activity] GO:0005006[epidermal growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007611[learning or memory] GO:0008284[positive regulation of cell population proliferation] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010008[endosome membrane] GO:0010750[positive regulation of nitric oxide mediated signal transduction] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019899[enzyme binding] GO:0019900[kinase binding] GO:0019903[protein phosphatase binding] GO:0022008[neurogenesis] GO:0030054[cell junction] GO:0030235[nitric-oxide synthase regulator activity] GO:0030296[protein tyrosine kinase activator activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031901[early endosome membrane] GO:0031965[nuclear membrane] GO:0032587[ruffle membrane] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033674[positive regulation of kinase activity] GO:0034614[cellular response to reactive oxygen species] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0038127[ERBB signaling pathway] GO:0038134[ERBB2-EGFR signaling pathway] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042177[negative regulation of protein catabolic process] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0045121[membrane raft] GO:0045296[cadherin binding] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739[positive regulation of DNA repair] GO:0045740[positive regulation of DNA replication] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046328[regulation of JNK cascade] GO:0046718[viral entry into host cell] GO:0046777[protein autophosphorylation] GO:0048408[epidermal growth factor binding] GO:0048471[perinuclear region of cytoplasm] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050999[regulation of nitric-oxide synthase activity] GO:0051015[actin filament binding] GO:0051117[ATPase binding] GO:0051205[protein insertion into membrane] GO:0051897[positive regulation of protein kinase B signaling] GO:0070141[response to UV-A] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070435[Shc-EGFR complex] GO:0071276[cellular response to cadmium ion] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0097489[multivesicular body, internal vesicle lumen] GO:0097708[intracellular vesicle] GO:0098590[plasma membrane region] GO:0098609[cell-cell adhesion] GO:1900020[positive regulation of protein kinase C activity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1902895[positive regulation of miRNA transcription] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1905208[negative regulation of cardiocyte differentiation]
Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins