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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q33.1
Chromosome location (bp)
151771045 - 151812911
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein involved in various processes, such as stress granule formation and innate immunity 1,2,3,4,5. Plays an essential role in stress granule formation 6,7,8,9,10,11,12,13,14,15,16,17. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress 18,19,20,21,22,23,24,25,26. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations 27,28,29,30,31,32. Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency 33. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA 34. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends 35. Plays an essential role in innate immunity by promoting CGAS and RIGI activity 36,37. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS 38. Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles 39. Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA 40. May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR 41....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Immunity, Innate immunity, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
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Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
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E5RJU8 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1
Show all
Q5U0Q1 [Target identity:100%; Query identity:100%] Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; Uncharacterized protein DKFZp686L1159; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
