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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q27
Chromosome location (bp)
121816444 - 121823883
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cyclin
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0001939[female pronucleus] GO:0001940[male pronucleus] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006275[regulation of DNA replication] GO:0006351[DNA-templated transcription] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901[protein kinase binding] GO:0019904[protein domain specific binding] GO:0031100[animal organ regeneration] GO:0032355[response to estradiol] GO:0033762[response to glucagon] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043687[post-translational protein modification] GO:0044320[cellular response to leptin stimulus] GO:0044772[mitotic cell cycle phase transition] GO:0044843[cell cycle G1/S phase transition] GO:0045893[positive regulation of DNA-templated transcription] GO:0048146[positive regulation of fibroblast proliferation] GO:0051301[cell division] GO:0071314[cellular response to cocaine] GO:0071373[cellular response to luteinizing hormone stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0071407[cellular response to organic cyclic compound] GO:0071456[cellular response to hypoxia] GO:0071732[cellular response to nitric oxide] GO:0090102[cochlea development] GO:0097124[cyclin A2-CDK2 complex] GO:1990314[cellular response to insulin-like growth factor stimulus]
The Human Protein Atlas project is funded
