We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q24.2
Chromosome location (bp)
168576605 - 168582069
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002548[monocyte chemotaxis] GO:0002690[positive regulation of leukocyte chemotaxis] GO:0002725[negative regulation of T cell cytokine production] GO:0002726[positive regulation of T cell cytokine production] GO:0002826[negative regulation of T-helper 1 type immune response] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006935[chemotaxis] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007267[cell-cell signaling] GO:0008009[chemokine activity] GO:0009615[response to virus] GO:0010820[positive regulation of T cell chemotaxis] GO:0030593[neutrophil chemotaxis] GO:0032689[negative regulation of interferon-gamma production] GO:0032703[negative regulation of interleukin-2 production] GO:0032733[positive regulation of interleukin-10 production] GO:0035782[mature natural killer cell chemotaxis] GO:0042379[chemokine receptor binding] GO:0042803[protein homodimerization activity] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043547[positive regulation of GTPase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0048020[CCR chemokine receptor binding] GO:0048247[lymphocyte chemotaxis] GO:0050727[regulation of inflammatory response] GO:0051209[release of sequestered calcium ion into cytosol] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0070098[chemokine-mediated signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071346[cellular response to interferon-gamma] GO:0071347[cellular response to interleukin-1] GO:0071353[cellular response to interleukin-4] GO:0071356[cellular response to tumor necrosis factor] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0071636[positive regulation of transforming growth factor beta production] GO:0071663[positive regulation of granzyme B production] GO:0090023[positive regulation of neutrophil chemotaxis] GO:2000412[positive regulation of thymocyte migration] GO:2000503[positive regulation of natural killer cell chemotaxis] GO:2000513[positive regulation of granzyme A production] GO:2000518[negative regulation of T-helper 1 cell activation] GO:2000538[positive regulation of B cell chemotaxis] GO:2000553[positive regulation of T-helper 2 cell cytokine production] GO:2000556[positive regulation of T-helper 1 cell cytokine production] GO:2000558[positive regulation of immunoglobulin production in mucosal tissue] GO:2000562[negative regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000566[positive regulation of CD8-positive, alpha-beta T cell proliferation]
The Human Protein Atlas project is funded
