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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
High
Neuronal projections:
High
Synapses:
High
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
95.8
nTPM
HPA Brain:
133.7
nTPM
GTEx:
95.8
nTPM
FANTOM5:
1.7
Scaled Tags Per Million
Pig:
393.2
nTPM
Mouse:
80.6
nTPM
Allen mouse:
1.1
Expression energy
DORSAL RAPHE - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody HPA012763
Glial cells
Not detected
Immunohistochemical staining of human dorsal raphe shows rare projection positivity.
50 ฮผm
Neuronal cells
Not detected
Neuronal projections
Low
Synapses
Not detected
DORSAL RAPHE - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody CAB016249
Glial cells
Not detected
Immunohistochemical staining of human dorsal raphe shows moderate projection and synaptic positivity.
50 ฮผm
Neuronal cells
Not detected
Neuronal projections
Medium
Synapses
Medium
SUBSTANTIA NIGRA - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody HPA012763
Glial cells
Not detected
Immunohistochemical staining of human substantia nigra shows moderate projection positivity.
100 ฮผm
Neuronal cells
Not detected
Neuronal projections
Medium
Synapses
Not detected
SUBSTANTIA NIGRA - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody CAB016249
Glial cells
Not detected
Immunohistochemical staining of human substantia nigra shows strong projection positivity and moderate synaptic positivity.
100 ฮผm
Neuronal cells
Not detected
Neuronal projections
High
Synapses
Medium
SUBSTANTIA NIGRA - Extended tissue profilei
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody CAB078172
Glial cells
Not detected
Immunohistochemical staining of human substantia nigra shows strong cytoplasmic positivity in neurons.
100 ฮผm
Neuronal cells
High
Neuronal projections
High
Synapses
High
MIDBRAIN - HPA Brain RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
133.7
Sample id
Sample description
nTPM
Cuneiform nucleus nTPM: 8.4
2219
Male, age 76, both hemispheres
64.2
1833
Male, age 53, unknown
11.3
1830
Male, age 51, unknown
5.8
2586
Male, age 75, left hemisphere
1.5
2411
Female, age 72, unknown
1.0
2828
Female, age 72, unknown
0.5
1827
Male, age 72, unknown
0.1
1870
Female, age 42, unknown
0.0
2019
Male, age 18, unknown
0.0
2666
Male, age 74, left hemisphere
0.0
Dorsal raphe nucleus nTPM: 1.6
2750
Male, age 76, both hemispheres
3.4
2298
Female, age 72, unknown
1.5
2047
Male, age 72, unknown
1.2
2016
Female, age 72, unknown
1.1
1828
Male, age 53, unknown
0.7
Inferior colliculus nTPM: 0.1
1890
Male, age 53, unknown
0.5
2849
Male, age 72, unknown
0.2
1848
Female, age 42, unknown
0.0
2097
Female, age 72, unknown
0.0
Median raphe nucleus nTPM: 1.1
2220
Male, age 76, midline
1.1
Periaquaductal grey, anterior nTPM: 0.2
2502
Female, age 75, unknown
0.5
1795
Male, age 51, unknown
0.0
1947
Male, age 18, unknown
0.0
Periaquaductal grey, dorsal nTPM: 0.2
1840
Male, age 53, unknown
0.7
1831
Male, age 72, unknown
0.1
2464
Female, age 72, unknown
0.0
2850
Male, age 76, both hemispheres
0.0
Periaquaductal grey, lateral nTPM: 0.0
2053
Male, age 18, unknown
0.0
2140
Male, age 76, both hemispheres
0.0
2272
Male, age 74, both hemispheres
0.0
Pretectal area nTPM: 0.2
1944
Female, age 72, unknown
1.1
1815
Male, age 53, unknown
0.5
2667
Female, age 75, unknown
0.5
2007
Male, age 72, unknown
0.1
1816
Male, age 51, unknown
0.0
1817
Female, age 42, unknown
0.0
2224
Female, age 72, unknown
0.0
2273
Male, age 74, both hemispheres
0.0
2316
Male, age 76, right hemisphere
0.0
2407
Male, age 75, both hemispheres
0.0
2825
Male, age 18, unknown
0.0
Red nucleus nTPM: 0.8
2584
Male, age 75, left hemisphere
5.5
2769
Male, age 72, unknown
1.7
2725
Female, age 75, unknown
0.7
1821
Female, age 72, unknown
0.6
1904
Male, age 53, unknown
0.6
2227
Male, age 72, unknown
0.3
2785
Male, age 18, unknown
0.1
1865
Male, age 51, unknown
0.0
1954
Female, age 42, unknown
0.0
2503
Female, age 72, unknown
0.0
2588
Male, age 74, left hemisphere
0.0
2823
Male, age 76, right hemisphere
0.0
Substantia nigra nTPM: 133.7
2699
Male, age 18, unknown
306.5
1916
Female, age 42, unknown
279.1
2665
Male, age 74, both hemispheres
244.3
2241
Male, age 72, unknown
122.9
1851
Male, age 51, unknown
120.5
1941
Male, age 53, unknown
117.4
2409
Female, age 72, unknown
96.4
2590
Female, age 75, unknown
21.5
1889
Female, age 72, unknown
20.2
2583
Male, age 75, right hemisphere
7.6
Superior colliculus nTPM: 0.2
2087
Female, age 72, unknown
0.7
2668
Female, age 75, unknown
0.7
1796
Male, age 53, unknown
0.6
1995
Male, age 72, unknown
0.1
1839
Male, age 51, unknown
0.0
1895
Male, age 76, right hemisphere
0.0
1913
Female, age 42, unknown
0.0
2261
Male, age 18, unknown
0.0
2587
Male, age 74, left hemisphere
0.0
2664
Male, age 75, both hemispheres
0.0
Ventral tegmental area nTPM: 71.2
1915
Female, age 42, unknown
169.8
2218
Male, age 76, both hemispheres
115.2
2410
Female, age 72, unknown
88.6
1942
Male, age 51, unknown
48.2
2223
Female, age 72, unknown
4.9
2021
Male, age 53, unknown
0.7
MIDBRAIN - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
95.8
GTEx sample id
Sample description
nTPM
Brain - Substantia nigra Average nTPM: 95.8
Samples: 139
Max nTPM: 423.7
Min nTPM: 0.0
Std nTPM: 112.4
Median nTPM: 50.3
GTEX-13OW6-0011-R2a-SM-5L3HG
50-59 years, male
423.7
GTEX-1313W-0011-R2a-SM-5EGLF
50-59 years, female
413.1
GTEX-1B8L1-0011-R2a-SM-9OSVL
60-69 years, male
387.2
GTEX-15ER7-0011-R2a-SM-6M46O
20-29 years, female
364.1
GTEX-13O3Q-0011-R2b-SM-5KM3K
50-59 years, male
363.3
GTEX-1LH75-0011-R2b-SM-EYYWQ
50-59 years, female
357.0
GTEX-15DYW-0011-R2b-SM-7KUKY
60-69 years, female
353.8
GTEX-15CHQ-0011-R2b-SM-6AJAD
60-69 years, male
324.3
GTEX-1HB9E-0011-R2b-SM-A96RW
50-59 years, male
323.2
GTEX-1EMGI-0011-R2b-SM-9OSVS
60-69 years, male
322.7
GTEX-1GN73-0011-R2a-SM-CJI2V
60-69 years, male
322.5
GTEX-11GSP-0011-R2b-SM-9QEGE
60-69 years, female
321.1
GTEX-1399T-0011-R2b-SM-5DUXM
60-69 years, male
319.1
GTEX-12WSD-0011-R2a-SM-5LZWB
60-69 years, female
308.0
GTEX-14BIN-0011-R2a-SM-5S2RJ
50-59 years, female
303.7
GTEX-12ZZX-0011-R2a-SM-5EGLG
40-49 years, female
282.8
GTEX-1B933-0011-R2b-SM-7IGNM
50-59 years, female
279.4
GTEX-1EKGG-0011-R2a-SM-CE6R8
60-69 years, male
263.2
GTEX-13OW8-0011-R2a-SM-5L3G2
60-69 years, male
254.7
GTEX-13G51-0011-R2b-SM-5LZXS
60-69 years, male
243.1
GTEX-13SLX-0011-R2b-SM-5S2VP
50-59 years, female
224.0
GTEX-XLM4-0011-R2B-SM-4AT5Z
60-69 years, male
214.3
GTEX-13O3O-0011-R2b-SM-5P9H1
60-69 years, female
213.3
GTEX-13FXS-0011-R2b-SM-5K7XX
50-59 years, male
210.3
GTEX-14BIM-0011-R2b-SM-69LQ6
60-69 years, female
197.4
GTEX-WHSE-0011-R2A-SM-3P5ZL
20-29 years, male
192.9
GTEX-X585-0011-R2B-SM-46MVF
50-59 years, male
183.1
GTEX-12WSF-0011-R2a-SM-5DUVU
70-79 years, male
182.8
GTEX-1F6I4-0011-R2a-SM-CL536
60-69 years, male
178.3
GTEX-T6MN-0011-R2A-SM-32QOW
50-59 years, male
168.9
GTEX-13RTJ-0011-R2a-SM-5PNW9
60-69 years, male
167.2
GTEX-11GSO-0011-R2a-SM-57WDF
60-69 years, male
163.6
GTEX-QMR6-0011-R2A-SM-32PKV
50-59 years, male
160.9
GTEX-T2IS-0011-R2A-SM-32QPF
20-29 years, female
160.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK
50-59 years, male
149.7
GTEX-1GMR8-0011-R2a-SM-CE6RD
50-59 years, female
142.6
GTEX-14C5O-0011-R2a-SM-5ZZV2
60-69 years, male
142.5
GTEX-145LS-0011-R2a-SM-5PNZI
60-69 years, female
138.6
GTEX-15DCD-0011-R2b-SM-6LPIE
70-79 years, female
138.4
GTEX-11WQC-0011-R2a-SM-DO927
60-69 years, male
133.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ
60-69 years, male
125.5
GTEX-1E1VI-0011-R2a-SM-9QEGS
50-59 years, male
122.0
GTEX-14ASI-0011-R2b-SM-5YY9H
60-69 years, male
115.7
GTEX-13N2G-0011-R2a-SM-5MR4Q
60-69 years, male
113.8
GTEX-1A3MX-0011-R2b-SM-7EWFL
60-69 years, male
110.3
GTEX-YFC4-0011-R2a-SM-4V6DZ
40-49 years, female
106.8
GTEX-13NYS-0011-R2b-SM-5MR4G
60-69 years, male
105.5
GTEX-11PRG-0011-R2a-SM-69LQ5
50-59 years, male
105.4
GTEX-T5JC-0011-R2A-SM-32PLZ
20-29 years, male
104.4
GTEX-15RJE-0011-R2b-SM-79OMP
40-49 years, male
96.8
GTEX-13QJC-0011-R2b-SM-5PNUN
60-69 years, female
91.0
GTEX-1IY9M-0011-R2a-SM-D4P29
60-69 years, male
90.7
GTEX-147GR-0011-R2b-SM-5S2RQ
60-69 years, male
88.1
GTEX-17EVP-0011-R2a-SM-7LG4W
40-49 years, male
77.5
GTEX-14JG1-0011-R2a-SM-5ZZVE
40-49 years, male
77.2
GTEX-14PJO-0011-R2a-SM-5ZZVF
60-69 years, male
75.8
GTEX-18464-0011-R2a-SM-731AL
50-59 years, male
74.7
GTEX-16Z82-0011-R2b-SM-79OK9
60-69 years, male
72.2
GTEX-1B996-0011-R2a-SM-7IGON
60-69 years, male
64.4
GTEX-1I1CD-0011-R2a-SM-CM2T3
60-69 years, female
64.2
GTEX-1GN2E-0011-R2a-SM-9WG7D
60-69 years, male
63.4
GTEX-NPJ7-0011-R2a-SM-2I3GF
60-69 years, female
62.0
GTEX-14PN4-0011-R2a-SM-6EU2Y
50-59 years, male
61.7
GTEX-1F6IF-0011-R2b-SM-9QEHB
60-69 years, male
58.7
GTEX-1H3O1-0011-R2b-SM-CKZOT
60-69 years, male
57.5
GTEX-1A8G7-0011-R2a-SM-7IGQI
60-69 years, male
55.4
GTEX-S7SE-0011-R2A-SM-2XCDC
50-59 years, male
55.3
GTEX-17HG3-0011-R2a-SM-7MGVX
30-39 years, female
54.5
GTEX-ZV68-0011-R2a-SM-4YCDK
50-59 years, female
51.0
GTEX-11EMC-0011-R2b-SM-DO114
60-69 years, female
50.3
GTEX-R55E-0011-R2A-SM-EYYV9
20-29 years, male
48.8
GTEX-13CF2-0011-R2a-SM-5L3DC
60-69 years, male
44.8
GTEX-QDT8-0011-R2A-SM-32PKQ
30-39 years, female
44.5
GTEX-P44G-0011-R2A-SM-2XCD2
30-39 years, male
41.8
GTEX-XMD1-0011-R2B-SM-4AT5N
60-69 years, male
37.8
GTEX-1LVAO-0011-R2a-SM-EYYX1
60-69 years, male
36.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q
70-79 years, male
36.1
GTEX-NL4W-0011-R2a-SM-2I5GV
50-59 years, male
34.9
GTEX-11ZTS-0011-R2b-SM-5BC75
60-69 years, female
33.6
GTEX-RU72-0011-R2A-SM-2TF6O
50-59 years, female
33.1
GTEX-11GS4-0011-R2a-SM-DO942
60-69 years, male
29.7
GTEX-1I1GV-0011-R2a-SM-ARZLF
60-69 years, male
28.8
GTEX-1B8SG-0011-R2b-SM-79OOT
50-59 years, male
28.3
GTEX-1IL2U-0011-R2a-SM-ARU6V
60-69 years, male
28.2
GTEX-13X6K-0011-R2b-SM-5P9K3
60-69 years, female
27.8
GTEX-YJ89-0011-R2b-SM-4RGLT
60-69 years, male
27.6
GTEX-1EU9M-0011-R2b-SM-9QEH7
60-69 years, male
26.2
GTEX-NPJ8-0011-R2a-SM-2TC6M
40-49 years, male
22.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ
60-69 years, male
20.6
GTEX-PWO3-0011-R2A-SM-2S1OX
60-69 years, female
19.1
GTEX-1IGQW-0011-R2b-SM-D4P26
60-69 years, male
17.8
GTEX-15EO6-0011-R2a-SM-6M46R
50-59 years, male
17.2
GTEX-12WSA-0011-R2a-SM-57WDK
60-69 years, male
16.9
GTEX-12WSH-0011-R2a-SM-5GU68
50-59 years, male
16.9
GTEX-13PDP-0011-R2b-SM-5O9DH
60-69 years, male
13.7
GTEX-ZAB4-0011-R2a-SM-4RGNP
40-49 years, male
12.4
GTEX-11TUW-0011-R2b-SM-DO92T
60-69 years, male
11.4
GTEX-1F48J-0011-R2a-SM-CL535
50-59 years, female
10.9
GTEX-13OVJ-0011-R2b-SM-5L3GP
50-59 years, female
10.8
GTEX-13X6I-0011-R2b-SM-5PNWQ
60-69 years, male
10.7
GTEX-131XH-0011-R2b-SM-5DUVY
50-59 years, male
10.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z
60-69 years, male
8.1
GTEX-ZDXO-0011-R2b-SM-4WKFG
60-69 years, male
7.1
GTEX-1H23P-0011-R2a-SM-CKZP3
60-69 years, male
6.5
GTEX-1445S-0011-R2b-SM-5PNUH
60-69 years, male
5.7
GTEX-1GTWX-0011-R2b-SM-ADEH5
60-69 years, male
5.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO
40-49 years, male
4.9
GTEX-13SLW-0011-R2b-SM-5O9C6
70-79 years, male
4.1
GTEX-1H3VE-0011-R2a-SM-CE6SA
40-49 years, male
4.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ
60-69 years, male
3.9
GTEX-1F75B-0011-R2a-SM-ARL8I
50-59 years, male
3.1
GTEX-1HT8W-0011-R2a-SM-CMKH9
30-39 years, male
2.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ
50-59 years, male
2.2
GTEX-1IKOH-0011-R2a-SM-CMKHO
60-69 years, female
1.9
GTEX-1GN1U-0011-R2a-SM-CL53A
50-59 years, female
1.6
GTEX-1I1GS-0011-R2b-SM-CMKHG
60-69 years, male
1.6
GTEX-OHPN-0011-R2A-SM-2I5FB
60-69 years, female
1.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT
60-69 years, male
1.4
GTEX-UTHO-0011-R2A-SM-3GIKC
60-69 years, male
1.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4
50-59 years, male
1.2
GTEX-1HFI6-0011-R2a-SM-CMKH5
40-49 years, male
1.0
GTEX-1J1OQ-0011-R2b-SM-ARU88
40-49 years, female
0.9
GTEX-Z93S-0011-R2a-SM-4RGNG
50-59 years, male
0.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ
60-69 years, male
0.6
GTEX-11UD1-0011-R2b-SM-5BC6O
40-49 years, female
0.4
GTEX-Q2AG-0011-R2A-SM-2HMIT
40-49 years, female
0.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ
70-79 years, male
0.2
GTEX-1HR98-0011-R2a-SM-ARL7A
60-69 years, male
0.2
GTEX-139TS-0011-R2b-SM-5J1MX
60-69 years, male
0.1
GTEX-N7MS-0011-R2a-SM-2HML6
60-69 years, male
0.1
GTEX-N7MT-0011-R2a-SM-2I3GI
60-69 years, female
0.1
GTEX-OXRO-0011-R2A-SM-3NB1W
60-69 years, female
0.1
GTEX-11DZ1-0011-R2a-SM-DNZZM
50-59 years, male
0.1
GTEX-13NYB-0011-R2a-SM-5MR3C
40-49 years, male
0.0
GTEX-X4XX-0011-R2A-SM-3P623
60-69 years, male
0.0
GTEX-ZE9C-0011-R2a-SM-4WKGH
60-69 years, male
0.0
GTEX-1HSMO-0011-R2a-SM-CL553
60-69 years, male
0.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X
60-69 years, male
0.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ
50-59 years, male
0.0
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MIDBRAIN - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
80.6
Mouse sample
Sample description
nTPM
Midbrain nTPM: 80.6
Samples: 4
Max nTPM: 90.2
Min nTPM: 75.2
Sample A
Male
75.2
Sample B
Male
76.4
Sample C
Female
90.2
Sample D
Female
80.7
MIDBRAIN - Allen Mouse ISHi
In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.
Max subtype Expression energyi
Max subtype Expression energy is the value for the subtype with the largest average Expression energy across the subtype samples.