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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q22.1
Chromosome location (bp)
67170154 - 67175737
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
[Isoform 1]: May be involved in RNA splicing....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, mRNA processing, mRNA splicing
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q5TZN6 [Target identity:100%; Query identity:100%] Nucleolar protein 3 (Apoptosis repressor with CARD domain); Nucleolar protein 3 (Apoptosis repressor with CARD domain), isoform CRA_b; cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005123[death receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006376[mRNA splice site selection] GO:0006397[mRNA processing] GO:0006915[apoptotic process] GO:0008380[RNA splicing] GO:0014808[release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0035877[death effector domain binding] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0046872[metal ion binding] GO:0051259[protein complex oligomerization] GO:0089720[caspase binding] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903298[negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway] GO:1990001[inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
H3BUN4 [Direct mapping] Nucleolar protein 3 Q5TZN6 [Target identity:100%; Query identity:100%] Nucleolar protein 3 (Apoptosis repressor with CARD domain); Nucleolar protein 3 (Apoptosis repressor with CARD domain), isoform CRA_b; cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005123[death receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006376[mRNA splice site selection] GO:0006397[mRNA processing] GO:0006915[apoptotic process] GO:0008380[RNA splicing] GO:0014808[release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0035877[death effector domain binding] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0046872[metal ion binding] GO:0051259[protein complex oligomerization] GO:0089720[caspase binding] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903298[negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway] GO:1990001[inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
