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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q34
Chromosome location (bp)
113208193 - 113267108
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins 1,2,3,4,5,6,7,8,9,10,11. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme 12,13,14,15,16,17,18,19. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 20,21,22,23,24,25,26,27. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component 28,29,30,31,32,33,34,35. DCX(DET1-COP1) directs ubiquitination of JUN 36. DCX(DDB2) directs ubiquitination of XPC 37. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition 38,39,40. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication 41,42,43. DCX(DTL) directs autoubiquitination of DTL 44. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip 45. Is involved in ubiquitination of HOXA9 46. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 47. A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation 48. The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) 49,50. The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes 51. With CUL4B, contributes to ribosome biogenesis 52....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009).[supplied by OMIM, Oct 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0001701[in utero embryonic development] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0016567[protein ubiquitination] GO:0030097[hemopoiesis] GO:0030674[protein-macromolecule adaptor activity] GO:0030853[negative regulation of granulocyte differentiation] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031461[cullin-RING ubiquitin ligase complex] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0034644[cellular response to UV] GO:0035019[somatic stem cell population maintenance] GO:0042254[ribosome biogenesis] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048511[rhythmic process] GO:0051246[regulation of protein metabolic process] GO:0080008[Cul4-RING E3 ubiquitin ligase complex] GO:0097193[intrinsic apoptotic signaling pathway] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:2000001[regulation of DNA damage checkpoint] GO:2000819[regulation of nucleotide-excision repair]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0016567[protein ubiquitination] GO:0030674[protein-macromolecule adaptor activity] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031461[cullin-RING ubiquitin ligase complex] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0034644[cellular response to UV] GO:0042254[ribosome biogenesis] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048511[rhythmic process] GO:0080008[Cul4-RING E3 ubiquitin ligase complex] GO:0097193[intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0016567[protein ubiquitination] GO:0030674[protein-macromolecule adaptor activity] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031461[cullin-RING ubiquitin ligase complex] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0034644[cellular response to UV] GO:0042254[ribosome biogenesis] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048511[rhythmic process] GO:0080008[Cul4-RING E3 ubiquitin ligase complex] GO:0097193[intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082[G1/S transition of mitotic cell cycle] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0016567[protein ubiquitination] GO:0030674[protein-macromolecule adaptor activity] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031461[cullin-RING ubiquitin ligase complex] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0034644[cellular response to UV] GO:0042254[ribosome biogenesis] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048511[rhythmic process] GO:0080008[Cul4-RING E3 ubiquitin ligase complex] GO:0097193[intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
