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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q27
Chromosome location (bp)
122610108 - 122621066
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells 1,2. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001819[positive regulation of cytokine production] GO:0002314[germinal center B cell differentiation] GO:0002639[positive regulation of immunoglobulin production] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005134[interleukin-2 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007260[tyrosine phosphorylation of STAT protein] GO:0008284[positive regulation of cell population proliferation] GO:0030890[positive regulation of B cell proliferation] GO:0032729[positive regulation of interferon-gamma production] GO:0032740[positive regulation of interleukin-17 production] GO:0034105[positive regulation of tissue remodeling] GO:0042102[positive regulation of T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0048469[cell maturation] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0051607[defense response to virus] GO:0060255[regulation of macromolecule metabolic process] GO:0061470[T follicular helper cell differentiation] GO:0098586[cellular response to virus]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001819[positive regulation of cytokine production] GO:0002314[germinal center B cell differentiation] GO:0002639[positive regulation of immunoglobulin production] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005134[interleukin-2 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007260[tyrosine phosphorylation of STAT protein] GO:0008284[positive regulation of cell population proliferation] GO:0030890[positive regulation of B cell proliferation] GO:0032729[positive regulation of interferon-gamma production] GO:0032740[positive regulation of interleukin-17 production] GO:0034105[positive regulation of tissue remodeling] GO:0042102[positive regulation of T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0048469[cell maturation] GO:0050729[positive regulation of inflammatory response] GO:0050896[response to stimulus] GO:0051607[defense response to virus] GO:0060255[regulation of macromolecule metabolic process] GO:0061470[T follicular helper cell differentiation] GO:0098586[cellular response to virus]
The Human Protein Atlas project is funded
