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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Blood group antigen proteins CD markers Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q24.1
Chromosome location (bp)
74409289 - 74433958
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001649[osteoblast differentiation] GO:0001755[neural crest cell migration] GO:0001934[positive regulation of protein phosphorylation] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0021988[olfactory lobe development] GO:0030154[cell differentiation] GO:0030215[semaphorin receptor binding] GO:0030335[positive regulation of cell migration] GO:0031175[neuron projection development] GO:0045499[chemorepellent activity] GO:0045773[positive regulation of axon extension] GO:0048675[axon extension] GO:0048843[negative regulation of axon extension involved in axon guidance] GO:0050727[regulation of inflammatory response] GO:0050919[negative chemotaxis] GO:0060907[positive regulation of macrophage cytokine production] GO:0062023[collagen-containing extracellular matrix] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071526[semaphorin-plexin signaling pathway]
CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649[osteoblast differentiation] GO:0001755[neural crest cell migration] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007229[integrin-mediated signaling pathway] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030154[cell differentiation] GO:0030215[semaphorin receptor binding] GO:0030335[positive regulation of cell migration] GO:0045499[chemorepellent activity] GO:0045773[positive regulation of axon extension] GO:0048843[negative regulation of axon extension involved in axon guidance] GO:0050727[regulation of inflammatory response] GO:0050919[negative chemotaxis] GO:0060907[positive regulation of macrophage cytokine production] GO:0062023[collagen-containing extracellular matrix] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071526[semaphorin-plexin signaling pathway]
The Human Protein Atlas project is funded
