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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q23.1
Chromosome location (bp)
111726908 - 111766389
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000159[protein phosphatase type 2A complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0019888[protein phosphatase regulator activity] GO:0045121[membrane raft] GO:0060561[apoptotic process involved in morphogenesis] GO:0070062[extracellular exosome] GO:2001241[positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159[protein phosphatase type 2A complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0019888[protein phosphatase regulator activity] GO:0045121[membrane raft] GO:0060561[apoptotic process involved in morphogenesis] GO:0070062[extracellular exosome] GO:2001241[positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159[protein phosphatase type 2A complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0019888[protein phosphatase regulator activity] GO:0045121[membrane raft] GO:0060561[apoptotic process involved in morphogenesis] GO:0070062[extracellular exosome] GO:2001241[positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159[protein phosphatase type 2A complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0019888[protein phosphatase regulator activity] GO:0045121[membrane raft] GO:0060561[apoptotic process involved in morphogenesis] GO:0070062[extracellular exosome] GO:2001241[positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159[protein phosphatase type 2A complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0019888[protein phosphatase regulator activity] GO:0045121[membrane raft] GO:0060561[apoptotic process involved in morphogenesis] GO:0070062[extracellular exosome] GO:2001241[positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the lung and pleura Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
