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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q12.1
Chromosome location (bp)
58552924 - 58582859
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis 1. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 2. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis 3. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types 4. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) 5. May also play a role in vesicular trafficking 6. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway 7....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0002091[negative regulation of receptor internalization] GO:0004222[metalloendopeptidase activity] GO:0005109[frizzled binding] GO:0005137[interleukin-5 receptor binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005895[interleukin-5 receptor complex] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006508[proteolysis] GO:0006612[protein targeting to membrane] GO:0006930[substrate-dependent cell migration, cell extension] GO:0007265[Ras protein signal transduction] GO:0007268[chemical synaptic transmission] GO:0007346[regulation of mitotic cell cycle] GO:0008022[protein C-terminus binding] GO:0008093[cytoskeletal anchor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0019838[growth factor binding] GO:0030036[actin cytoskeleton organization] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031965[nuclear membrane] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035255[ionotropic glutamate receptor binding] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0042043[neurexin family protein binding] GO:0042327[positive regulation of phosphorylation] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0044877[protein-containing complex binding] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045545[syndecan binding] GO:0046330[positive regulation of JNK cascade] GO:0046875[ephrin receptor binding] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0050839[cell adhesion molecule binding] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0072562[blood microparticle] GO:0098793[presynapse] GO:0099054[presynapse assembly] GO:1903543[positive regulation of exosomal secretion] GO:1903553[positive regulation of extracellular exosome assembly] GO:1903561[extracellular vesicle]
Transporters Accessory Factors Involved in Transport Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0002091[negative regulation of receptor internalization] GO:0004222[metalloendopeptidase activity] GO:0005109[frizzled binding] GO:0005137[interleukin-5 receptor binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005895[interleukin-5 receptor complex] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006508[proteolysis] GO:0006612[protein targeting to membrane] GO:0006930[substrate-dependent cell migration, cell extension] GO:0007268[chemical synaptic transmission] GO:0007346[regulation of mitotic cell cycle] GO:0008093[cytoskeletal anchor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020[membrane] GO:0030036[actin cytoskeleton organization] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031965[nuclear membrane] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0042327[positive regulation of phosphorylation] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0045121[membrane raft] GO:0045545[syndecan binding] GO:0046330[positive regulation of JNK cascade] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0072562[blood microparticle] GO:1903543[positive regulation of exosomal secretion] GO:1903553[positive regulation of extracellular exosome assembly] GO:1903561[extracellular vesicle]
Transporters Accessory Factors Involved in Transport Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0002091[negative regulation of receptor internalization] GO:0004222[metalloendopeptidase activity] GO:0005109[frizzled binding] GO:0005137[interleukin-5 receptor binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005895[interleukin-5 receptor complex] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006508[proteolysis] GO:0006612[protein targeting to membrane] GO:0006930[substrate-dependent cell migration, cell extension] GO:0007268[chemical synaptic transmission] GO:0007346[regulation of mitotic cell cycle] GO:0008093[cytoskeletal anchor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020[membrane] GO:0030036[actin cytoskeleton organization] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031965[nuclear membrane] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0042327[positive regulation of phosphorylation] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0045121[membrane raft] GO:0045545[syndecan binding] GO:0046330[positive regulation of JNK cascade] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0072562[blood microparticle] GO:1903543[positive regulation of exosomal secretion] GO:1903553[positive regulation of extracellular exosome assembly] GO:1903561[extracellular vesicle]
Transporters Accessory Factors Involved in Transport Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0002091[negative regulation of receptor internalization] GO:0004222[metalloendopeptidase activity] GO:0005109[frizzled binding] GO:0005137[interleukin-5 receptor binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005895[interleukin-5 receptor complex] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006508[proteolysis] GO:0006612[protein targeting to membrane] GO:0006930[substrate-dependent cell migration, cell extension] GO:0007268[chemical synaptic transmission] GO:0007346[regulation of mitotic cell cycle] GO:0008093[cytoskeletal anchor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0016020[membrane] GO:0030036[actin cytoskeleton organization] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031965[nuclear membrane] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035556[intracellular signal transduction] GO:0035578[azurophil granule lumen] GO:0042327[positive regulation of phosphorylation] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0045121[membrane raft] GO:0045545[syndecan binding] GO:0046330[positive regulation of JNK cascade] GO:0046982[protein heterodimerization activity] GO:0047485[protein N-terminus binding] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0072562[blood microparticle] GO:1903543[positive regulation of exosomal secretion] GO:1903553[positive regulation of extracellular exosome assembly] GO:1903561[extracellular vesicle]
Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
B4DHN5 [Direct mapping] Syntenin-1; cDNA FLJ55055, moderately similar to Syntenin-1
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Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
G5EA09 [Direct mapping] Syndecan binding protein (Syntenin), isoform CRA_a; Syntenin-1
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Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
G5EA09 [Direct mapping] Syndecan binding protein (Syntenin), isoform CRA_a; Syntenin-1
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Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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