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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p24.1
Chromosome location (bp)
6215786 - 6257983
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells 1,2. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines 3,4. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells 5,6. Acts as an enhancer of polarization of alternatively activated macrophages 7. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury 8,9. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0010186[positive regulation of cellular defense response] GO:0010628[positive regulation of gene expression] GO:0030133[transport vesicle] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0038172[interleukin-33-mediated signaling pathway] GO:0043032[positive regulation of macrophage activation] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050729[positive regulation of inflammatory response] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0120042[negative regulation of macrophage proliferation] GO:0150078[positive regulation of neuroinflammatory response] GO:0150142[positive regulation of CD86 production] GO:0150145[positive regulation of CD80 production]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0010186[positive regulation of cellular defense response] GO:0010628[positive regulation of gene expression] GO:0030133[transport vesicle] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0038172[interleukin-33-mediated signaling pathway] GO:0043032[positive regulation of macrophage activation] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050729[positive regulation of inflammatory response] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0120042[negative regulation of macrophage proliferation] GO:0150078[positive regulation of neuroinflammatory response] GO:0150142[positive regulation of CD86 production] GO:0150145[positive regulation of CD80 production]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0010186[positive regulation of cellular defense response] GO:0010628[positive regulation of gene expression] GO:0030133[transport vesicle] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0038172[interleukin-33-mediated signaling pathway] GO:0043032[positive regulation of macrophage activation] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050729[positive regulation of inflammatory response] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0120042[negative regulation of macrophage proliferation] GO:0150078[positive regulation of neuroinflammatory response] GO:0150142[positive regulation of CD86 production] GO:0150145[positive regulation of CD80 production]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0010186[positive regulation of cellular defense response] GO:0010628[positive regulation of gene expression] GO:0030133[transport vesicle] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0038172[interleukin-33-mediated signaling pathway] GO:0043032[positive regulation of macrophage activation] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050729[positive regulation of inflammatory response] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0120042[negative regulation of macrophage proliferation] GO:0150078[positive regulation of neuroinflammatory response] GO:0150142[positive regulation of CD86 production] GO:0150145[positive regulation of CD80 production]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001819[positive regulation of cytokine production] GO:0002112[interleukin-33 receptor binding] GO:0002281[macrophage activation involved in immune response] GO:0002282[microglial cell activation involved in immune response] GO:0002638[negative regulation of immunoglobulin production] GO:0002639[positive regulation of immunoglobulin production] GO:0002686[negative regulation of leukocyte migration] GO:0002826[negative regulation of T-helper 1 type immune response] GO:0002830[positive regulation of type 2 immune response] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0006606[protein import into nucleus] GO:0010186[positive regulation of cellular defense response] GO:0010467[gene expression] GO:0010628[positive regulation of gene expression] GO:0030133[transport vesicle] GO:0030225[macrophage differentiation] GO:0031410[cytoplasmic vesicle] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032689[negative regulation of interferon-gamma production] GO:0032722[positive regulation of chemokine production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032754[positive regulation of interleukin-5 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0038172[interleukin-33-mediated signaling pathway] GO:0042060[wound healing] GO:0042092[type 2 immune response] GO:0043032[positive regulation of macrophage activation] GO:0043231[intracellular membrane-bounded organelle] GO:0045345[positive regulation of MHC class I biosynthetic process] GO:0045348[positive regulation of MHC class II biosynthetic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0050729[positive regulation of inflammatory response] GO:0051607[defense response to virus] GO:0051770[positive regulation of nitric-oxide synthase biosynthetic process] GO:0051930[regulation of sensory perception of pain] GO:0061518[microglial cell proliferation] GO:0071260[cellular response to mechanical stimulus] GO:0097191[extrinsic apoptotic signaling pathway] GO:0120042[negative regulation of macrophage proliferation] GO:0150078[positive regulation of neuroinflammatory response] GO:0150142[positive regulation of CD86 production] GO:0150145[positive regulation of CD80 production]
The Human Protein Atlas project is funded
