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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q14.1
Chromosome location (bp)
113099315 - 113134016
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P18510 [Direct mapping] Interleukin-1 receptor antagonist protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002437[inflammatory response to antigenic stimulus] GO:0005125[cytokine activity] GO:0005149[interleukin-1 receptor binding] GO:0005150[interleukin-1, type I receptor binding] GO:0005151[interleukin-1, type II receptor binding] GO:0005152[interleukin-1 receptor antagonist activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0045352[interleukin-1 type I receptor antagonist activity] GO:0045353[interleukin-1 type II receptor antagonist activity] GO:0051384[response to glucocorticoid] GO:0070062[extracellular exosome] GO:2000660[negative regulation of interleukin-1-mediated signaling pathway]
P18510 [Direct mapping] Interleukin-1 receptor antagonist protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002437[inflammatory response to antigenic stimulus] GO:0005125[cytokine activity] GO:0005149[interleukin-1 receptor binding] GO:0005150[interleukin-1, type I receptor binding] GO:0005151[interleukin-1, type II receptor binding] GO:0005152[interleukin-1 receptor antagonist activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0045352[interleukin-1 type I receptor antagonist activity] GO:0045353[interleukin-1 type II receptor antagonist activity] GO:0051384[response to glucocorticoid] GO:0070062[extracellular exosome] GO:2000660[negative regulation of interleukin-1-mediated signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002437[inflammatory response to antigenic stimulus] GO:0005125[cytokine activity] GO:0005149[interleukin-1 receptor binding] GO:0005150[interleukin-1, type I receptor binding] GO:0005151[interleukin-1, type II receptor binding] GO:0005152[interleukin-1 receptor antagonist activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0045352[interleukin-1 type I receptor antagonist activity] GO:0045353[interleukin-1 type II receptor antagonist activity] GO:0051384[response to glucocorticoid] GO:0070062[extracellular exosome] GO:2000660[negative regulation of interleukin-1-mediated signaling pathway]
P18510 [Direct mapping] Interleukin-1 receptor antagonist protein
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001960[negative regulation of cytokine-mediated signaling pathway] GO:0002437[inflammatory response to antigenic stimulus] GO:0005125[cytokine activity] GO:0005149[interleukin-1 receptor binding] GO:0005150[interleukin-1, type I receptor binding] GO:0005151[interleukin-1, type II receptor binding] GO:0005152[interleukin-1 receptor antagonist activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0030073[insulin secretion] GO:0031982[vesicle] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0045352[interleukin-1 type I receptor antagonist activity] GO:0045353[interleukin-1 type II receptor antagonist activity] GO:0051384[response to glucocorticoid] GO:0070062[extracellular exosome] GO:2000660[negative regulation of interleukin-1-mediated signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
