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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q24.2
Chromosome location (bp)
159712457 - 159771027
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates 1. May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis 2. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'- linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 3. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006513[protein monoubiquitination] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031624[ubiquitin conjugating enzyme binding] GO:0043130[ubiquitin binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051865[protein autoubiquitination] GO:0097371[MDM2/MDM4 family protein binding] GO:1901799[negative regulation of proteasomal protein catabolic process] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1902916[positive regulation of protein polyubiquitination] GO:1905524[negative regulation of protein autoubiquitination]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002643[regulation of tolerance induction] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006513[protein monoubiquitination] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019899[enzyme binding] GO:0031624[ubiquitin conjugating enzyme binding] GO:0042130[negative regulation of T cell proliferation] GO:0043130[ubiquitin binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051865[protein autoubiquitination] GO:0097371[MDM2/MDM4 family protein binding] GO:1901799[negative regulation of proteasomal protein catabolic process] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1902916[positive regulation of protein polyubiquitination] GO:1905524[negative regulation of protein autoubiquitination]
Enzymes ENZYME proteins Transferases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006513[protein monoubiquitination] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031624[ubiquitin conjugating enzyme binding] GO:0043130[ubiquitin binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051865[protein autoubiquitination] GO:0097371[MDM2/MDM4 family protein binding] GO:1901799[negative regulation of proteasomal protein catabolic process] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1902916[positive regulation of protein polyubiquitination] GO:1905524[negative regulation of protein autoubiquitination]
The Human Protein Atlas project is funded
