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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p22.1
Chromosome location (bp)
6374527 - 6403967
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles 1,2,3,4. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity 5. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts 6. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX 7. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
GTP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A4D2P1 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a; Ras-related C3 botulinum toxin substrate 1 isoform Rac1; cDNA FLJ30431 fis, clone BRACE2008968, highly similar to Ras-related C3 botulinum toxin substrate 1; cDNA FLJ75553, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0003924[GTPase activity] GO:0003925[G protein activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005789[endoplasmic reticulum membrane] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0005938[cell cortex] GO:0006954[inflammatory response] GO:0007015[actin filament organization] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007163[establishment or maintenance of cell polarity] GO:0007264[small GTPase mediated signal transduction] GO:0008045[motor neuron axon guidance] GO:0008360[regulation of cell shape] GO:0008361[regulation of cell size] GO:0009611[response to wounding] GO:0009653[anatomical structure morphogenesis] GO:0010310[regulation of hydrogen peroxide metabolic process] GO:0010591[regulation of lamellipodium assembly] GO:0010592[positive regulation of lamellipodium assembly] GO:0010595[positive regulation of endothelial cell migration] GO:0010764[negative regulation of fibroblast migration] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0016477[cell migration] GO:0016601[Rac protein signal transduction] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030031[cell projection assembly] GO:0030032[lamellipodium assembly] GO:0030036[actin cytoskeleton organization] GO:0030041[actin filament polymerization] GO:0030334[regulation of cell migration] GO:0030425[dendrite] GO:0030667[secretory granule membrane] GO:0030865[cortical cytoskeleton organization] GO:0031116[positive regulation of microtubule polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031529[ruffle organization] GO:0031996[thioesterase binding] GO:0032587[ruffle membrane] GO:0032707[negative regulation of interleukin-23 production] GO:0032956[regulation of actin cytoskeleton organization] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035025[positive regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042470[melanosome] GO:0042995[cell projection] GO:0043020[NADPH oxidase complex] GO:0043197[dendritic spine] GO:0043652[engulfment of apoptotic cell] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045428[regulation of nitric oxide biosynthetic process] GO:0045730[respiratory burst] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048870[cell motility] GO:0051022[Rho GDP-dissociation inhibitor binding] GO:0051179[localization] GO:0051492[regulation of stress fiber assembly] GO:0051496[positive regulation of stress fiber assembly] GO:0051668[localization within membrane] GO:0051894[positive regulation of focal adhesion assembly] GO:0055038[recycling endosome membrane] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0060090[molecular adaptor activity] GO:0060263[regulation of respiratory burst] GO:0070062[extracellular exosome] GO:0071526[semaphorin-plexin signaling pathway] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0097178[ruffle assembly] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0101003[ficolin-1-rich granule membrane] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1902622[regulation of neutrophil migration]
A4D2P0 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e; cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA
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Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001764[neuron migration] GO:0001934[positive regulation of protein phosphorylation] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0003924[GTPase activity] GO:0003925[G protein activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005789[endoplasmic reticulum membrane] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0005938[cell cortex] GO:0006954[inflammatory response] GO:0007015[actin filament organization] GO:0007155[cell adhesion] GO:0007160[cell-matrix adhesion] GO:0007163[establishment or maintenance of cell polarity] GO:0007264[small GTPase mediated signal transduction] GO:0008045[motor neuron axon guidance] GO:0008360[regulation of cell shape] GO:0008361[regulation of cell size] GO:0009611[response to wounding] GO:0009653[anatomical structure morphogenesis] GO:0010310[regulation of hydrogen peroxide metabolic process] GO:0010591[regulation of lamellipodium assembly] GO:0010592[positive regulation of lamellipodium assembly] GO:0010595[positive regulation of endothelial cell migration] GO:0010764[negative regulation of fibroblast migration] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016020[membrane] GO:0016477[cell migration] GO:0016601[Rac protein signal transduction] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030031[cell projection assembly] GO:0030032[lamellipodium assembly] GO:0030036[actin cytoskeleton organization] GO:0030041[actin filament polymerization] GO:0030334[regulation of cell migration] GO:0030425[dendrite] GO:0030667[secretory granule membrane] GO:0030865[cortical cytoskeleton organization] GO:0031116[positive regulation of microtubule polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031529[ruffle organization] GO:0031996[thioesterase binding] GO:0032587[ruffle membrane] GO:0032707[negative regulation of interleukin-23 production] GO:0032956[regulation of actin cytoskeleton organization] GO:0034446[substrate adhesion-dependent cell spreading] GO:0035025[positive regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042470[melanosome] GO:0042995[cell projection] GO:0043020[NADPH oxidase complex] GO:0043197[dendritic spine] GO:0043652[engulfment of apoptotic cell] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045428[regulation of nitric oxide biosynthetic process] GO:0045730[respiratory burst] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048870[cell motility] GO:0051022[Rho GDP-dissociation inhibitor binding] GO:0051179[localization] GO:0051492[regulation of stress fiber assembly] GO:0051496[positive regulation of stress fiber assembly] GO:0051668[localization within membrane] GO:0051894[positive regulation of focal adhesion assembly] GO:0055038[recycling endosome membrane] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0060090[molecular adaptor activity] GO:0060263[regulation of respiratory burst] GO:0070062[extracellular exosome] GO:0071526[semaphorin-plexin signaling pathway] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0097178[ruffle assembly] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0101003[ficolin-1-rich granule membrane] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1902622[regulation of neutrophil migration]
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)